Fecal microbiota transfer for treating initial Clostridioides difficile infections

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the use of fecal microbiota transfer (FMT) via retention enema as a treatment for patients experiencing their first episode of Clostridioides difficile infection (CDI). The approach aims to restore the gut microbiota, which is often disrupted by antibiotic treatments, thereby reducing the risk of recurrence. Participants will receive either the FMT or a placebo enema, and the study will assess the effectiveness of this method in preventing CDI recurrence. The study is conducted at multiple hospitals in Finland, focusing on patients who meet specific eligibility criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* \>18 years
* C. difficile PCR in feces positive and clinical symptoms of enteritis.
* Full resolution of diarrhea during antibiotic treatment for C. difficile
* No other ongoing antibacterial treatments.
* No ongoing probiotics.
* Signed informed consent.

Exclusion Criteria:

* Pregnant
* Ongoing need for antibacterial treatment
* Life expectancy \< 1 year
* Prior C. difficile infection in preceding 3 months
* Unable to provide written consent, due to dementia for example.
* Fecal incontinence i.e. inability to retain enema.

Where it's running

• Turku University hospital
  Turku, Finland Recruiting

Study contacts

• Study coordinator: Teppo U Stenholm
• Email: teppo.stenholm@tyks.fi
• Phone: 023130000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Preventing C. difficile recurrence with short-course oral vancomycin during later antibiotics

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• UDCA added to standard therapy to prevent C. diff recurrence

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.