How gut bacteria and bile acids affect Clostridioides difficile infections in patients with inflammatory bowel disease.
The impact of inflammation induced alterations to microbially derived bile acids on susceptibility and severity of Clostridioides difficile infection
This study is looking at how the bacteria in your gut and certain substances called bile acids might affect the risk of Clostridioides difficile infections in people with inflammatory bowel disease, and it will also test if adding specific bile acids can help make these infections less severe.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10873907 on NIH RePORTER |
What this research studies
This research investigates the relationship between gut microbiota, bile acids, and Clostridioides difficile infections (CDI) in patients with inflammatory bowel disease (IBD). It aims to understand how inflammation alters the gut microbiome and bile acid composition, potentially increasing susceptibility to CDI. The study will explore whether supplementing with specific bile acids can reduce the severity of CDI in IBD patients. By examining these interactions, the research seeks to identify preventative measures for those at higher risk of CDI.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with inflammatory bowel disease who are at risk for Clostridioides difficile infections.
Not a fit: Patients without inflammatory bowel disease or those not at risk for Clostridioides difficile infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating Clostridioides difficile infections in patients with inflammatory bowel disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of gut microbiota in infections, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Winston, Jenessa Andrzejewski — Ohio State University
- Study coordinator: Winston, Jenessa Andrzejewski
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.