Understanding immune responses to Clostridioides difficile infections
Immune profiling to stratify Clostridioides difficile infection outcomes
['FUNDING_OTHER'] · UNIVERSITY OF VIRGINIA · NIH-10865000
This study is looking at how the immune system reacts to Clostridioides difficile infections to help doctors understand which patients might be at greater risk for serious problems, so they can provide better care and treatment.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-10865000 on ClinicalTrials.gov |
What this research studies
This research focuses on how the immune system responds to Clostridioides difficile infections, which are a major healthcare concern. The team will create a detailed database of patients with these infections, analyzing various immune markers and the presence of specific toxins to predict patient outcomes. By studying factors like eosinophil levels and certain biomarkers, the goal is to develop a model that can help identify which patients are at higher risk of severe outcomes. This approach aims to improve treatment strategies and patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Clostridioides difficile infections, particularly those experiencing severe symptoms or complications.
Not a fit: Patients who do not have Clostridioides difficile infections or those with mild, uncomplicated cases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prediction and management of Clostridioides difficile infections, ultimately improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using immune profiling to predict outcomes in infectious diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MADDEN, GREGORY RUSSELL — UNIVERSITY OF VIRGINIA
- Study coordinator: MADDEN, GREGORY RUSSELL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.