Identifying immune responses to Clostridioides difficile infection
Identification of the antigenic targets of the clonal antibody response to Clostridioides difficile infection
This study is looking at how your immune system fights off Clostridioides difficile infection by examining special immune cells in your blood, which could help create better treatments and prevention methods just for you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10886133 on NIH RePORTER |
What this research studies
This research investigates how the immune system responds to Clostridioides difficile infection (CDI) by analyzing specific immune cells called plasmablasts in patients. By collecting blood samples from individuals who have experienced CDI, researchers will isolate these cells and study the antibodies they produce. This approach aims to identify the specific antigens targeted by the immune response, which could lead to improved prevention strategies and therapies for CDI. The findings may help tailor treatments based on individual immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have recently experienced Clostridioides difficile infection, both children and adults.
Not a fit: Patients who have not had a Clostridioides difficile infection or those with chronic conditions unrelated to CDI may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective prevention and treatment options for Clostridioides difficile infection.
How similar studies have performed: Other research has shown promise in understanding immune responses to infections, but this specific approach to CDI is relatively novel.
Where this research is happening
Chicago, United States
- Lurie Children's Hospital of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Kociolek, Larry K — Lurie Children's Hospital of Chicago
- Study coordinator: Kociolek, Larry K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.