A blood test to check immunity against Clostridioides difficile infection
A Serological Assay for Neutralizing Antitoxin Response in Patients with Clostridioides difficile Infection (Phase II)
This study is working on a new blood test to see if people who have had a Clostridioides difficile infection have enough antibodies to stop it from coming back, making it easier to manage the infection and reduce the chances of it returning.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fzata, INC. NIH-funded |
| Lab location | 1 site (Halethorpe, United States) |
| Project ID | NIH-10682402 on NIH RePORTER |
What this research studies
This research focuses on developing a blood test that can determine if patients infected with Clostridioides difficile have produced enough neutralizing antibodies to prevent the infection from recurring. The current treatment methods often lead to high rates of recurrence due to the disruption of gut microbiota. By using a novel serological assay, the researchers aim to provide a quicker and more standardized method for measuring these antibodies, which could help in managing the infection more effectively. The study involves collaboration with experienced organizations to ensure the test's reliability and predictive capabilities.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with Clostridioides difficile infection and are undergoing treatment.
Not a fit: Patients who have not been diagnosed with Clostridioides difficile infection or those who are not currently receiving treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the recurrence of Clostridioides difficile infections, improving patient outcomes and quality of life.
How similar studies have performed: Previous research has shown promise in developing similar serological assays, indicating a potential for success in this novel approach.
Where this research is happening
Halethorpe, United States
- Fzata, INC. — Halethorpe, United States (Active)
Researchers
- Principal investigator: Yang, Zhiyong — Fzata, INC.
- Study coordinator: Yang, Zhiyong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.