Laparoscopic splenectomy's effect on liver function in cirrhosis patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of laparoscopic splenectomy on liver reserve function in patients diagnosed with cirrhosis. Participants undergo the surgical procedure, and their liver function indicators are monitored at multiple time points post-surgery. The goal is to determine if this surgical intervention can enhance liver function and improve overall patient prognosis. A standardized treatment and follow-up plan is implemented to ensure consistency in patient care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* A clinical, radiological or histologic diagnosis of cirrhosis of any etiology
* Splenomegaly with secondary hypersplenism, Platelet count \< 50\*10\^9/L
* Informed consent to participate in the study

Exclusion Criteria:

* Hepatocellular carcinoma or any other malignancy,
* Child-Pugh grade C
* Recent peptic ulcer disease
* History of Hemorrhagic stroke
* Pregnancy.
* Uncontrolled Hypertension
* Bleeding portal hypertension
* Human immunodeficiency virus (HIV) infection

Where it's running

• Clinical Medical College of Yangzhou University
  Yangzhou, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Guo-Qing Jiang, MD
• Email: jgqing2003@hotmail.com
• Phone: +8651487373272

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Education to prevent infections after spleen removal

  See if a targeted educational program for adults who had their spleen removed improves vaccination uptake, awareness of infection risk, and continuity of care.

  Recruiting at 2 sites Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Rome, Lazio and 1 other locations · NCT07354893

• Laparoscopic surgery to improve immune function in cirrhosis patients

  This study is testing if a specific type of surgery can help boost the immune system in people with liver cirrhosis who have an enlarged spleen.

  Recruiting Northern Jiangsu People's Hospital · Yangzhou, Jiangsu · NCT05338294

• Surgery to improve liver function in cirrhosis patients

  This study tests whether a specific surgery can help improve liver function in patients with cirrhosis who have an enlarged spleen.

  Recruiting Northern Jiangsu People's Hospital · Yangzhou, Jiangsu · NCT05325437

• Italian questionnaire to measure knowledge and vaccination attitudes in people without a spleen

  This project will test a new Italian questionnaire to measure how much people without a spleen know about infection prevention and vaccination.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Rome, Lazio · NCT07428005

• Laparoscopic partial removal of the spleen for hypersplenism in cirrhosis.

  This test tries whether removing part of the spleen by laparoscopy improves immune function and recovery in people with cirrhosis and hypersplenism.

  Recruiting Northern Jiangsu People's Hospital · Yangzhou, Jiangsu · NCT07205471

• Vaccination for patients without a spleen

  This study is testing if the meningococcal B vaccine is safe and effective for people who don’t have a spleen compared to healthy individuals.

  Recruiting Phase 2 Medical University of Vienna · Vienna, State of Vienna · NCT06025487

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.