Does high abdominal pressure cause microaspiration in ventilated patients with cirrhosis?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study monitors intra-abdominal pressure by measuring bladder (intra-vesical) pressure every eight hours during the first two days of mechanical ventilation. Tracheal suction samples will be tested for pepsin or amylase to define microaspiration. Patients will be grouped by presence or absence of intra-abdominal hypertension (IAH) and compared for rates of microaspiration. Eligible participants are adult patients with cirrhosis who are intubated and can have intra-vesical pressure measured, excluding pregnant or oliguric patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* adult patients
* Cirrhosis
* intubation and mechanical ventilation

Exclusion Criteria:

* pregnancy
* oliguric patients
* impossibility to measure intravesical pressure

Where it's running

• Hop Claude Huriez Chu Lille
  Lille, France Recruiting
• Hop Salengro - Hopital B
  Lille, France Recruiting

Study contacts

• Principal investigator: Saad Nseir, MD,PhD — University Hospital, Lille
• Study coordinator: Saad Nseir, MD,PhD
• Email: saadalla.nseir@chru-lille.fr
• Phone: 0320444495

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.