Finding blood markers to detect colorectal cancer in people under 50.
Discovery and verification of methylated circulating tumor DNA markers for the detection of colorectal cancer in subjects under 50 years of age
This study is working on a simple blood test to help find colorectal cancer in people under 50, so that those who might be at risk can get checked out early and get the care they need.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10880613 on NIH RePORTER |
What this research studies
This research aims to develop a blood test that can identify colorectal cancer in individuals under 50 years of age, a group that currently lacks effective screening options. By analyzing circulating tumor DNA (ctDNA) in blood plasma, the study seeks to discover specific methylated DNA markers that indicate the presence of cancer. This minimally invasive approach could help identify young patients who need further examination, such as a colonoscopy, thereby improving early detection and treatment outcomes. The research addresses the rising incidence of colorectal cancer in younger populations and aims to enhance screening adherence among those at risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 50 years of age who may be at risk for colorectal cancer.
Not a fit: Patients over 50 years of age or those without risk factors for colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a simple blood test that allows for earlier detection of colorectal cancer in younger individuals, potentially saving lives.
How similar studies have performed: Other research has shown promise in using blood-based tests for cancer detection, making this approach both innovative and grounded in prior successes.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Hitchins, Megan P — Cedars-Sinai Medical Center
- Study coordinator: Hitchins, Megan P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.