Analyzing urine for cancer-related DNA
Urine based circulating tumor DNA analysis
This study is looking at whether testing urine can help detect cancer-related DNA in patients with non-metastatic HPV positive throat cancer, and it aims to see if this at-home urine test is as good as the usual blood tests and biopsies for keeping track of the disease and spotting any recurrences.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10870078 on NIH RePORTER |
What this research studies
This research investigates the use of urine as a source for circulating tumor DNA in patients with non-genitourinary cancers, particularly focusing on those with non-metastatic HPV positive oropharyngeal cancer. The study aims to establish the feasibility and effectiveness of at-home urine-based molecular testing compared to traditional methods like blood tests and tissue biopsies. By comparing the sensitivity and specificity of urine-based HPV testing to established gold standards, the research seeks to improve disease monitoring and recurrence detection for these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-metastatic HPV positive oropharyngeal cancer.
Not a fit: Patients with metastatic cancers or those not infected with oncogenic HPV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a non-invasive and convenient method for monitoring cancer recurrence in patients.
How similar studies have performed: Other research has shown promising results using blood-based HPV DNA testing, suggesting that urine-based testing may also be effective.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Lautenschlaeger, Tim — Indiana University Indianapolis
- Study coordinator: Lautenschlaeger, Tim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.