Condition

Locally Advanced Rectal Carcinoma clinical trials and research

• 8Clinical trials
• 5Countries

Newest Locally Advanced Rectal Carcinoma clinical trials

All recruiting trials (8)

• Triplet vs doublet induction therapy with chemoradiotherapy for high-risk locally advanced rectal cancer, followed by surgery or watch-and-wait

  This trial tests whether a triplet induction chemotherapy (FOLFOXIRI) before chemoradiotherapy improves response and long-term outcomes in high-risk locally advanced rectal cancer compared with a doublet induction (CAPOX/FOLFOX).

  Recruiting at 10 sites Phase 3 Catharina Ziekenhuis Eindhoven · Arnhem, Gelderland and 19 other locations · NCT07472868

• Adding modulated electro‑hyperthermia to total neoadjuvant therapy for locally advanced rectal cancer

  This trial tests whether adding modulated electro‑hyperthermia (mEHT) to total neoadjuvant therapy helps adults with locally advanced rectal cancer achieve more tumor down‑staging and higher rates of complete pathological response.

  Recruiting Phase 3 Dalin Tzu Chi General Hospital · Chiayi City, Dalin Township · NCT07372300

• Combining chemoradiotherapy with immunotherapy for advanced rectal cancer

  This study is testing whether adding an immunotherapy drug to standard treatment can help people with advanced rectal cancer feel better and improve their quality of life.

  Recruiting at 2 sites Phase 2/3 Beijing Friendship Hospital · Beijing, Beijing Municipality and 1 other locations · NCT06312982

• Exercise to enhance chemoradiotherapy effectiveness in advanced rectal cancer patients

  This study is testing if an 11-week exercise program can help people with advanced rectal cancer get better results from their chemoradiotherapy treatment.

  Recruiting Early Phase 1 University of Hull · Cottingham, East Yorkshire · NCT06276686

• Comparing two methods for preserving organs in rectal cancer patients

  This study is testing two different ways to treat rectal cancer in patients who responded well to initial treatment, to see which method helps them keep their organs and improve their quality of life.

  Recruiting at 7 sites The Netherlands Cancer Institute · Nijmegen, Gelderland and 6 other locations · NCT05772923

• Neoadjuvant treatment for locally advanced rectal cancer using Serplulimab, CAPEOX, and Celecoxib

  This study is testing a new treatment combining an immune therapy and chemotherapy to see if it can help people with locally advanced rectal cancer before surgery.

  Recruiting Phase 2 Zhejiang University · Hangzhou, Zhejiang · NCT05731726

• Using circulating tumor DNA to guide treatment for advanced rectal cancer

  This study is testing if using a blood test to check for tumor DNA can help doctors give better treatment to people with advanced rectal cancer by personalizing their therapy based on their risk of recurrence.

  Recruiting Phase 2 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT05601505

• Short course radiation therapy combined with chemotherapy for stage II-III rectal cancer

  This study is testing a new treatment plan that combines short radiation therapy with chemotherapy to see if it helps people with stage II-III rectal cancer feel better and have fewer problems after treatment.

  Recruiting Phase 1 Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT04703101

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Quick answers

How many Locally Advanced Rectal Carcinoma clinical trials are recruiting right now?

8, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in China (3 trials), Netherlands (2 trials), United Kingdom (1 trial), United States (1 trial), Taiwan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 2: 2, Early Phase 1: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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