Using liquid biopsies and breath samples to detect lung cancer mutations

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the feasibility of recruiting participants and utilizing various biological samples, including sputum, bronchoalveolar lavage (BAL), and exhaled volatile organic compounds (VOC), alongside blood, to detect mutations in cell-free DNA in patients with non-small cell lung cancer (NSCLC). The study will follow patients undergoing surgical resection for NSCLC-adenocarcinoma, collecting samples at multiple time points before and after surgery, as well as during follow-up visits over a 24-month period. The goal is to evaluate the potential of these samples as novel biomarkers for monitoring disease recurrence and treatment response.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient must be at least 18 years of age
* Patient must be able to provide consent
* Patients undergoing surgical resection with curative intent for non-small cell lung cancer at St. Joseph's Healthcare Hamilton and Firestone Institute for Respiratory Health.

Exclusion Criteria:

* Resection done with non-curative intent or metastatic disease
* other malignancies
* Patients with previously treated malignancy less than 5 years prior to current resection (not including skin cancer).

Where it's running

• St. Joseph's Healthcare Hamilton
  Hamilton, Ontario, Canada Recruiting

Study contacts

• Study coordinator: Layla Halwagi, BSc
• Email: Lhalwagi@stjosham.on.ca
• Phone: 905-522-1155

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.