Using blood and MRI to monitor glioma treatment effectiveness
Integrating circulating tumor DNA assay and protein-based MRI to accurately monitor glioma therapy
This study is looking at a new way to check how well glioma treatments are working by using blood tests and special MRI scans, so patients can get quick and easy updates on their progress without needing to have surgery for tissue samples.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10878885 on NIH RePORTER |
What this research studies
This research investigates a new method to monitor the effectiveness of glioma treatments by combining two advanced techniques: analyzing circulating tumor DNA (ctDNA) from blood samples and using protein-based MRI scans. The goal is to provide real-time, noninvasive insights into how well a patient is responding to treatment, which is crucial given the challenges of obtaining tumor tissue for analysis. By integrating these approaches, the research aims to improve the accuracy of monitoring glioma therapy and help guide treatment decisions.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioma who are undergoing treatment with temozolomide chemo-radiotherapy.
Not a fit: Patients with other types of brain tumors or those not receiving glioma-specific treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective monitoring of glioma treatments, allowing for timely adjustments to therapy based on individual patient responses.
How similar studies have performed: Previous studies have shown promise in using liquid biopsies and advanced MRI techniques for cancer monitoring, indicating that this combined approach could be effective.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Jiang, Shanshan — Johns Hopkins University
- Study coordinator: Jiang, Shanshan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.