Effect of revascularization on small vessel disease in carotid artery stenosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study involves a prospective cohort of 1,000 patients with carotid artery stenosis who will either undergo revascularization therapy or receive standard medication treatment. The primary aim is to determine if revascularization can reduce the progression of cerebral small vessel disease and improve related retinal pathologies and cognitive impairment. Participants aged 40 and older with significant stenosis will be recruited and undergo various imaging and neuropsychological assessments over an estimated follow-up period of up to 10 years.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients aged ≥ 40 years.
2. ≥ 50% stenosis in unilateral carotid artery.
3. Sign informed consent.

Exclusion Criteria:

1. Previous history of major head trauma and any intracranial surgery
2. Intracranial abnormalities, such as intracerebral hemorrhage, subarachnoid hemorrhage, and other space occupying lesions
3. Extrapyramidal symptoms or mental illness which may affect neuropsychological measurement.
4. Severe loss of vision, hearing, or communicative ability.

Where it's running

• Zhejiang Provincial People's Hospital
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Sheng Zhang, M.D.
• Email: zhangsheng@hmc.edu.cn
• Phone: +8618758188313

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Photon-counting CT vs conventional CT for carotid plaque in people with carotid artery stenosis

  This study tests whether photon-counting CT gives clearer, more detailed pictures of carotid plaques compared with standard CT in patients with carotid artery stenosis to help characterize plaque features.

  Recruiting Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT07762664

• Can QSM MRI help tell MS from age-related brain changes in older adults

  This study tests whether an advanced MRI technique called QSM can better differentiate MS-related brain lesions from age-related or small vessel changes in people aged 50–70.

  Recruiting Oslo University Hospital · Oslo, Oslo · NCT07444047

• Carotid artery stent for people with carotid narrowing who are high risk for surgery

  This study will try a carotid artery stent system in adults with carotid artery narrowing who are considered high risk for carotid endarterectomy.

  Recruiting at 16 sites Beijing Tiantan Hospital · Beijing, Beijing Municipality and 15 other locations · NCT07370246

• Registry for people with cerebral small vessel disease.

  This project will collect clinical information and MRI scans from people aged 50 and older with MRI signs of cerebral small vessel disease to see how the condition relates to thinking, walking, and daily function over time.

  Recruiting Dongzhimen Hospital, Beijing · Beijing, Beijing Municipality · NCT07342075

• Balloon guide catheter plus filter protection during carotid artery stenting

  This trial tests whether adding a balloon guide catheter to the usual distal filter during carotid artery stenting reduces debris-related brain injury in adults with symptomatic (≥50%) or asymptomatic (≥70%) carotid stenosis scheduled for stenting.

  Recruiting Beijing Anzhen Hospital · Beijing, Beijing Municipality · NCT07247864

• Ultra-Intensive Lipid-Lowering Therapy in Carotid Artery Stenosis: PCSK9 Inhibitor Plus Statin vs Statin Alone

  This study tests whether adding a PCSK9 inhibitor to statin therapy improves the amount of atherosclerosis in people with carotid artery stenosis compared to statin therapy alone.

  Recruiting Changhai Hospital · Shanghai · NCT07036991

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.