Effect of revascularization on small vessel disease in carotid artery stenosis
Revascularization Effect on CSVD Burden in Carotid Artery Stenosis
Zhejiang Provincial People's Hospital · NCT06031610
This study is testing if a procedure to improve blood flow in the carotid artery can help prevent brain and eye problems in people with narrowed arteries.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 40 Years to 80 Years |
| Sex | All |
| Sponsor | Zhejiang Provincial People's Hospital (other) |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT06031610 on ClinicalTrials.gov |
What this trial studies
This observational study involves a prospective cohort of 1,000 patients with carotid artery stenosis who will either undergo revascularization therapy or receive standard medication treatment. The primary aim is to determine if revascularization can reduce the progression of cerebral small vessel disease and improve related retinal pathologies and cognitive impairment. Participants aged 40 and older with significant stenosis will be recruited and undergo various imaging and neuropsychological assessments over an estimated follow-up period of up to 10 years.
Who should consider this trial
Good fit: Ideal candidates are patients aged 40 years and older with more than 50% stenosis in a unilateral carotid artery.
Not a fit: Patients with a history of major head trauma, intracranial abnormalities, or severe sensory impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into more effective treatment options for patients with carotid artery stenosis and related cognitive impairments.
How similar studies have performed: While similar studies have explored revascularization effects, this specific approach focusing on cerebral small vessel disease in carotid artery stenosis is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients aged ≥ 40 years. 2. ≥ 50% stenosis in unilateral carotid artery. 3. Sign informed consent. Exclusion Criteria: 1. Previous history of major head trauma and any intracranial surgery 2. Intracranial abnormalities, such as intracerebral hemorrhage, subarachnoid hemorrhage, and other space occupying lesions 3. Extrapyramidal symptoms or mental illness which may affect neuropsychological measurement. 4. Severe loss of vision, hearing, or communicative ability.
Where this trial is running
Hangzhou, Zhejiang
- Zhejiang Provincial People's Hospital — Hangzhou, Zhejiang, China (RECRUITING)
Study contacts
- Study coordinator: Sheng Zhang, M.D.
- Email: zhangsheng@hmc.edu.cn
- Phone: +8618758188313
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Carotid Artery Stenosis, Cerebral Small Vessel Diseases, Revascularization, Carotid artery stenting, prospective cohort