Evaluating retinal health in patients with cerebral small vessel disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients with cerebral small vessel disease (CSVD), a condition that significantly affects older adults and is linked to stroke and dementia. It utilizes optical coherence tomography angiography (OCTA), a non-invasive imaging technology, to assess retinal and choroidal health and its correlation with CSVD markers. The study aims to explore the relationship between OCTA-derived parameters and CSVD, providing insights into the potential clinical value of these measurements for screening and monitoring patients. By analyzing these parameters, the research seeks to enhance understanding of CSVD and its implications for brain health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Older than 35 years old;
2. Patients who underwent Multimodal MRI with any CSVD imaging marker;
3. Subjects who have signed informed consent.

Exclusion Criteria:

1. Patient who was unable to cooperate with examinations;
2. There are known diseases that may cause or worsen CSVD (brain injury, Down syndrome, Alzheimer's disease, Parkinson's disease, etc.);
3. There are known eye diseases or severe underlying fundus lesions that may impact fundus assessment;
4. Suffering from serious systemic diseases, such as heart, liver, kidney diseases or major mental illnesses;
5. Contraindications for imaging examinations

Exit Criteria:

1. Not meet the inclusion criteria.
2. For any poor adherence, not comply with the requirements of the follow-up, or safety reasons determined by investigator.
3. Any adverse or serious adverse events during the study period judged by investigator

Where it's running

• Zhejiang Provincial People's Hospital
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Sheng Zhang
• Email: zhangsheng@hmc.edu.cn
• Phone: +8618758188313

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.