Registry for young and middle-aged patients with cerebral small vessel diseases and dementia risk

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the relationship between cerebral small vessel diseases (CSVD) and cognitive impairment in individuals aged 30 to 60 years who show imaging markers of CSVD but do not have known dementia. Participants will undergo neuropsychological assessments and multimodal MRI scans, along with Optical Coherence Tomography Angiography (OCTA) to evaluate retinal health. The study will collect clinical data and follow participants over time to better understand the progression of cognitive decline in this demographic. By focusing on younger patients, the study seeks to fill a gap in knowledge regarding CSVD's impact on cognitive health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients with any of the CSVD-related MRI imaging markers, including recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and superficial cortical siderosis.
2. Patients aged from 30 to 60 years.
3. Sign informed consent.

Exclusion Criteria:

1. Unable to cooperate with inspectors.
2. Known dementia.
3. Other cognitive diseases (such as Alzheimer's disease, Parkinson's disease, or thyroid disease).
4. Serious systemic illness, such as heart, liver, kidney disease or major mental illness.
5. Contraindications for imaging examination.

Exit Criteria:

1. Not meet the inclusion criteria.
2. For any poor adherence, not comply with the requirements of the follow-up, or safety reasons determined by investigator.
3. Any adverse or serious adverse events during the study period judged by investigator.

Where it's running

• Zhejiang Provincial People's Hospital
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Sheng Zhang, M.D.
• Email: zhangsheng@hmc.edu.cn
• Phone: +8618758188313

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.