Registry for people with cerebral small vessel disease.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational registry enrolling adults aged 50 and older with MRI-confirmed cerebral small vessel disease. Participants will undergo standardized MRI (including diffusion tensor imaging), clinical evaluations, and cognitive testing at baseline and at planned follow-up visits to track changes over time. Key exclusions include recent large stroke or intracranial hemorrhage, significant non-vascular white matter disease, and other known causes of cognitive impairment to keep the cohort specific to CSVD. Collected data aim to link imaging features with clinical and cognitive outcomes to inform future targeted interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age above 50 years (including 50-year-old);
2. MRI confirmed the presence of typical imaging changes of CSVD;
3. Voluntary participation in the study and be willing to sign the Informed Consent Form.

Exclusion Criteria:

1. Patients with acute ischemic stroke or acute intracranial hemorrhage (e.g., epidural hematoma, subdural hematoma, subarachnoid hemorrhage, intracerebral hemorrhage, etc.) or a history of cerebral infarction (non-lacunar) or intracranial hemorrhage within the past 3 months;
2. Significant non-vascular white matter lesions (e.g., multiple sclerosis, adult-onset leukoencephalopathy, metabolic encephalopathy, etc.);
3. Patients with a history of cognitive impairment due to other causes (e.g., normal pressure hydrocephalus, Alzheimer's disease, Parkinson's disease, multiple sclerosis, encephalitis, etc.);
4. Severe hepatic, renal, or cardiac insufficiency (ALT or AST \>2 times the upper limit of normal, or serum creatinine \>1.5 times the upper limit of normal, or New York Heart Association \[NYHA\] functional class III or IV);
5. Patients with psychiatric disorders that affect study medication administration and evaluation;
6. Contraindications to MRI examination (e.g., claustrophobia, presence of an implantable pacemaker, etc.);
7. Patients unable to comply with follow-up examinations or other study procedures due to residential location or other reasons;
8. Participation in other clinical trial projects.

Where it's running

• Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Beida Ren, PhD
• Email: 18810900836@163.com
• Phone: +86-18810900836

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.