Investigating inflammation and blood vessel changes in brain diseases related to aging
Official title: Perivascular Inflammation and Vascular Remodeling: A Common Cause of Hemorrhage in Cerebral Small Vessel Diseases?
Funded at Massachusetts General Hospital · NIH-10861499 · Data updated 2026-11-12
This study is looking at how inflammation and changes in blood vessels can cause bleeding in the brain, especially for people with conditions like cerebral amyloid angiopathy and arteriolosclerosis, to find new ways to help prevent these dangerous issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $776,503 |
| NIH project number | 1R56NS131387-01 |
| Project ID | NIH-10861499 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults diagnosed with cerebral small vessel diseases, particularly those with cerebral amyloid angiopathy.
✕Less likely to help
Patients with other types of dementia or those without any vascular issues in the brain may not benefit from this research.
What this research studies
This research focuses on understanding how inflammation around blood vessels and changes in their structure may lead to bleeding in the brain, particularly in conditions like cerebral amyloid angiopathy and arteriolosclerosis. By examining brain tissue from patients who have passed away and using advanced imaging techniques in mouse models, the study aims to uncover the mechanisms that contribute to these dangerous vascular changes. The goal is to identify new treatment targets that could prevent or reduce the risk of hemorrhage in patients with cerebral small vessel disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent brain hemorrhages in patients with cerebral small vessel diseases.
How similar studies have gone: Previous research has shown promise in understanding the role of vascular changes in brain diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Van Veluw, Susanne Janneke — Massachusetts General Hospital
- Study coordinator: Van Veluw, Susanne Janneke
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.