Exploring the relationship between large artery atherosclerosis and small vessel disease in the brain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the mutual effects of intracranial large artery atherosclerosis and cerebral small vessel disease on disease progression and prognosis using magnetic resonance imaging (MRI). It aims to understand the feedback mechanisms between these two conditions, which are often interconnected and can worsen clinical outcomes such as stroke and dementia. By identifying biomarkers through MRI, the study seeks to enhance early prevention and treatment strategies for cerebrovascular diseases.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* At least one intracranial artery ≥ 50% atherosclerotic stenosis
* Modified Rankin Scale \< 2
* Mini-mental State Examination \> 24

Exclusion Criteria:

* Concurrent ipsilateral extracranial artery ≥ 50% stenosis
* Pregnant women
* Contraindications to magnetic resonance examination (patients with pacemakers, nerve stimulators, artificial metal heart valves and other metal foreign bodies)

Where it's running

• Chinese PLA General Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Jinhao Lyu — Chinese PLA General Hospital
• Study coordinator: Jinhao Lyu
• Email: 330322990@qq.com
• Phone: +8615903562929

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.