Exploring the relationship between large artery atherosclerosis and small vessel disease in the brain
Feedback Loop Between Intracranial Atherosclerosis and Cerebral Small Vessel Disease
This study looks at how large artery blockages and small blood vessel problems in the brain affect each other and worsen conditions like stroke and dementia, using MRI to find ways to prevent and treat these issues better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 30 Years and up |
| Sex | All |
| Sponsor | Chinese PLA General Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT05677607 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the mutual effects of intracranial large artery atherosclerosis and cerebral small vessel disease on disease progression and prognosis using magnetic resonance imaging (MRI). It aims to understand the feedback mechanisms between these two conditions, which are often interconnected and can worsen clinical outcomes such as stroke and dementia. By identifying biomarkers through MRI, the study seeks to enhance early prevention and treatment strategies for cerebrovascular diseases.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older with significant atherosclerotic stenosis in at least one intracranial artery.
Not a fit: Patients with concurrent significant stenosis in extracranial arteries or those with contraindications to MRI may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and treatment options for patients at risk of cerebrovascular diseases.
How similar studies have performed: While the specific feedback mechanisms are not fully understood, there is growing evidence supporting the coexistence of these conditions, indicating that similar studies may have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * At least one intracranial artery ≥ 50% atherosclerotic stenosis * Modified Rankin Scale \< 2 * Mini-mental State Examination \> 24 Exclusion Criteria: * Concurrent ipsilateral extracranial artery ≥ 50% stenosis * Pregnant women * Contraindications to magnetic resonance examination (patients with pacemakers, nerve stimulators, artificial metal heart valves and other metal foreign bodies)
Where this trial is running
Beijing, Beijing Municipality
- Chinese PLA General Hospital — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Principal investigator: Jinhao Lyu — Chinese PLA General Hospital
- Study coordinator: Jinhao Lyu
- Email: 330322990@qq.com
- Phone: +8615903562929
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.