Investigating genetic and non-genetic factors in small vessel disease
Official title: Deciphering, Construction and Validation of Magnetic Resonance Imaging Maps, Clinical Features and Outcomes in Genetic and Nongenetic Cerebral Small Vessel Diseases
Run by National Taiwan University Hospital · NCT05473637 · Data updated 2026-11-12
This study is trying to see how genetic and non-genetic factors affect people with small vessel disease in the brain by looking at their symptoms and MRI results over two years.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | National Taiwan University Hospital Academic / other |
| Locations | 1 site (Taipei) |
| Status | Recruiting |
| Started | January 1, 2019 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2028 |
| Registry record updated | January 20, 2026 |
| Trial ID | NCT05473637 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with symptoms such as stroke, cognitive impairment, gait disturbances, or a family history of hereditary CSVD.
✕Probably not a fit
Patients with CSVD due to other inflammatory, malignancy, or structural lesions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study enrolls patients exhibiting clinical and neuroimaging features of cerebral small vessel disease (CSVD). Participants will undergo next-generation sequencing (NGS) targeting five candidate genes associated with CSVD, allowing researchers to categorize them into genetic or non-genetic groups. The study aims to follow the clinical features and outcomes of these patients for a minimum of two years, utilizing MRI as a key diagnostic tool. By understanding the genetic and non-genetic factors involved, the study seeks to enhance the understanding of CSVD.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnosis and management strategies for patients with cerebral small vessel diseases.
How similar studies have gone: While the approach of using genetic sequencing in this context is relatively novel, similar studies have shown promise in understanding genetic contributions to other vascular conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Participants must have at least one of the following symptoms/signs or history * stroke (especially small vessel occlusion type of ischaemic stroke, spontaneous ICH or young stroke) * cognitive impairment or dementia * gait disturbance * parkinsonism (especially vascular parkinsonism features) * headache (especially migraine) * positive family history of hereditary CSVD * MRI evidence of CSVD (MRI may be done for other reasons), including mild to moderate white matter hyper intensity, any lacune, or any cerebral microbleed Exclusion Criteria: * MRI evidence of CSVD due to other inflammatory, malignancy, or structural lesions * patients or family members not willing to sign informed consent
Where it's running
-
Department of Neurology, National Taiwan University Hospital
Taipei, Taiwan Recruiting
Study contacts
- Study coordinator: Sung-Chun Tang, MD, PhD
- Email: sctang@ntuh.gov.tw
- Phone: 886972651113
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Deep phenotyping to explore recovery in young adults after stroke
This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.
-
Stem cell therapy for chronic stroke recovery
This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.
-
Fighting cognitive decline and dementia caused by small vessel disease
This study is trying to see how changes in the brain and eye blood vessels can help predict dementia risk in people over 60 with small vessel disease.
-
Treatment for neurologic disorders using stem cells
This study is testing whether using stem cells from patients' own bone marrow can help improve brain and nerve function in people with serious neurologic disorders that don't respond well to regular treatments.
-
AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals
This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.
-
Web-based therapy using action observation and mirror therapy for arm weakness after stroke
This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.