Clinical trial Recruiting at 1 site Phase 1 Interventional Ages 18 to 55

Examining how THC affects men and women differently

Official title: Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study II

Run by Yale University · NCT04704271 · Data updated 2026-11-12

This study is testing how vaporized THC affects men and women differently to see if their reactions vary based on gender.

Quick facts

PhasePhase 1
Study typeInterventional
Ages18 Years to 55 Years
SexAll
Enrollment100 (estimated)
SponsorYale University
Academic / other
Locations1 site (West Haven, Connecticut)
StatusRecruiting
StartedOctober 9, 2019
Main results expectedDecember 1, 2027
Study endsDecember 1, 2027
Registry record updatedApril 29, 2026
Trial IDNCT04704271 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are healthy individuals with at least one prior exposure to cannabis.

Probably not a fit

Patients who are cannabis naïve or experiencing major stressors may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate the acute effects of vaporized THC on healthy individuals, focusing on gender differences in response. It will involve administering THC and a placebo to participants who have prior cannabis exposure, while assessing their physical and mental health. The research seeks to understand the underlying mechanisms that contribute to any observed differences between men and women in their reactions to THC.

Why it matters

Potential benefit: If successful, this study could lead to more personalized cannabis treatments based on gender-specific responses.

How similar studies have gone: While there is ongoing research into the effects of cannabinoids, this specific focus on gender differences is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* At least one lifetime exposure to cannabis
* Good physical and mental health

Exclusion Criteria:

* Cannabis naïve individuals
* Major current or recent stressors

Where it's running

  • Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine
    West Haven, Connecticut, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.