Examining how THC affects men and women differently
Official title: Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study II
Run by Yale University · NCT04704271 · Data updated 2026-11-12
This study is testing how vaporized THC affects men and women differently to see if their reactions vary based on gender.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 55 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Yale University Academic / other |
| Locations | 1 site (West Haven, Connecticut) |
| Status | Recruiting |
| Started | October 9, 2019 |
| Main results expected | December 1, 2027 |
| Study ends | December 1, 2027 |
| Registry record updated | April 29, 2026 |
| Trial ID | NCT04704271 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy individuals with at least one prior exposure to cannabis.
✕Probably not a fit
Patients who are cannabis naïve or experiencing major stressors may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to investigate the acute effects of vaporized THC on healthy individuals, focusing on gender differences in response. It will involve administering THC and a placebo to participants who have prior cannabis exposure, while assessing their physical and mental health. The research seeks to understand the underlying mechanisms that contribute to any observed differences between men and women in their reactions to THC.
Why it matters
Potential benefit: If successful, this study could lead to more personalized cannabis treatments based on gender-specific responses.
How similar studies have gone: While there is ongoing research into the effects of cannabinoids, this specific focus on gender differences is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * At least one lifetime exposure to cannabis * Good physical and mental health Exclusion Criteria: * Cannabis naïve individuals * Major current or recent stressors
Where it's running
-
Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine
West Haven, Connecticut, United States Recruiting
Study contacts
- Study coordinator: Carly Hewes, BS
- Email: carly.hewes@yale.edu
- Phone: 2039325711
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.