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Clinical trial Recruiting at 1 site Phase 1 Interventional Ages 18 to 55

Examining how gender affects the immediate effects of THC in healthy individuals

Official title: Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study I

Run by Yale University · NCT02811510 · Data updated 2026-11-12

This study is testing how a synthetic form of THC affects healthy men and women differently to see if gender plays a role in its effects.

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Quick facts

PhasePhase 1
Study typeInterventional
Ages18 Years to 55 Years
SexAll
Enrollment40 (estimated)
SponsorYale University
Academic / other
Locations1 site (West Haven, Connecticut)
StatusRecruiting
StartedJune 2016
Main results expectedJune 2026
Study endsDecember 2026
Registry record updatedJune 10, 2025
Trial IDNCT02811510 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are healthy individuals with prior cannabis exposure, regardless of gender.

Probably not a fit

Patients who are cannabis naive or have significant stressors or hormonal treatments may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate the acute effects of Dronabinol, a synthetic form of THC, in healthy men and women. Participants will receive either a placebo or a 10 mg capsule of Dronabinol to assess how gender influences the drug's effects. The research will also explore the underlying mechanisms that may contribute to any observed differences between genders. By focusing on individuals with prior cannabis exposure, the study seeks to provide insights into gender-related responses to cannabinoids.

Why it matters

Potential benefit: If successful, this study could enhance understanding of how gender influences cannabinoid effects, leading to more personalized treatment approaches.

How similar studies have gone: While studies on cannabinoids exist, this specific focus on gender differences in acute effects is relatively novel and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* At least one lifetime exposure to cannabis
* Good physical and mental health

Exclusion Criteria:

* Cannabis naive individuals
* Major current or recent stressors
* Taking estrogen supplements or oral contraceptive pills (for women)
* Sesame oil allergy

Where it's running

  • Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine
    West Haven, Connecticut, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.