Using cannabis extract to relieve acute radicular pain and reduce painkiller needs
Official title: Effect of Cannabis Extract on Acute Radicular Pain and on Analgesic Requirement: A Double Blinded, Randomized, 24 Hours Follow-up Study
Run by Hadassah Medical Organization · NCT04816994 · Data updated 2026-11-12
This study is testing if cannabis oil can help hospitalized patients with severe pain feel better and use fewer painkillers like morphine.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Hadassah Medical Organization Academic / other |
| Locations | 1 site (Jerusalem) |
| Status | Recruiting |
| Started | January 7, 2018 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2025 |
| Registry record updated | October 2, 2025 |
| Trial ID | NCT04816994 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 to 70 experiencing acute radicular pain lasting less than 12 weeks with significant pain levels.
✕Probably not a fit
Patients with chronic pain conditions, recent opioid or cannabis use, or certain medical histories may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the effectiveness of cannabis oil in managing acute radicular pain and renal colic pain in hospitalized patients. Participants will receive a single dose of cannabis oil alongside standard pain management protocols, including morphine. The study aims to determine if cannabis can provide pain relief and decrease the reliance on opioid medications. Eligible patients will be monitored for pain levels and overall outcomes during their treatment.
Why it matters
Potential benefit: If successful, this study could offer a new pain management option that reduces the need for opioids in patients with acute radicular pain.
How similar studies have gone: While there is limited clinical evidence on cannabis for acute pain management, expert opinions suggest potential benefits, indicating this approach may be novel and underexplored.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 - 70 years * ASA 1 or 2 * Acute Radicular Pain \< 12 weeks * Pain of VAS 6 or more/ VRS moderate or more * Radicular pain: Dermatomal pain that corresponds to physical exam and CT/MRI in the last year Exclusion Criteria: * Age \< 18 or \> 70 years * ASA 3 or more * Chronic radicular pain \> 12 weeks * Past spine surgery * Intermittent Claudication due to Vascular Disease * Diagnosed Diabetic Neuropathy * Regular Cannabis use in past 6 months (more than once a week) OR once in last 2 weeks * Regular opioid use in past week (Targin, Percocet, Tramadol) (Equivalent to Oxycodone 20 mg/day or more) * Pregnancy or Lactating * Ischemic heart disease * Renal or hepatic failure * History of psychiatric illness * Cognitive impairment or inability to answer questions * Known allergy to opioids * Potential Loss to follow up
Where it's running
-
Hadassah Medical Center
Jerusalem, Israel Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.