Clinical trial Recruiting at 1 site Phase 3 Interventional Ages 18 to 70

Using cannabis extract to relieve acute radicular pain and reduce painkiller needs

Official title: Effect of Cannabis Extract on Acute Radicular Pain and on Analgesic Requirement: A Double Blinded, Randomized, 24 Hours Follow-up Study

Run by Hadassah Medical Organization · NCT04816994 · Data updated 2026-11-12

This study is testing if cannabis oil can help hospitalized patients with severe pain feel better and use fewer painkillers like morphine.

More Cannabis trials

Quick facts

PhasePhase 3
Study typeInterventional
Ages18 Years to 70 Years
SexAll
Enrollment200 (estimated)
SponsorHadassah Medical Organization
Academic / other
Locations1 site (Jerusalem)
StatusRecruiting
StartedJanuary 7, 2018
Main results expectedDecember 31, 2025
Study endsDecember 31, 2025
Registry record updatedOctober 2, 2025
Trial IDNCT04816994 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 to 70 experiencing acute radicular pain lasting less than 12 weeks with significant pain levels.

Probably not a fit

Patients with chronic pain conditions, recent opioid or cannabis use, or certain medical histories may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of cannabis oil in managing acute radicular pain and renal colic pain in hospitalized patients. Participants will receive a single dose of cannabis oil alongside standard pain management protocols, including morphine. The study aims to determine if cannabis can provide pain relief and decrease the reliance on opioid medications. Eligible patients will be monitored for pain levels and overall outcomes during their treatment.

Why it matters

Potential benefit: If successful, this study could offer a new pain management option that reduces the need for opioids in patients with acute radicular pain.

How similar studies have gone: While there is limited clinical evidence on cannabis for acute pain management, expert opinions suggest potential benefits, indicating this approach may be novel and underexplored.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age 18 - 70 years
* ASA 1 or 2
* Acute Radicular Pain \< 12 weeks
* Pain of VAS 6 or more/ VRS moderate or more
* Radicular pain: Dermatomal pain that corresponds to physical exam and CT/MRI in the last year

Exclusion Criteria:

* Age \< 18 or \> 70 years
* ASA 3 or more
* Chronic radicular pain \> 12 weeks
* Past spine surgery
* Intermittent Claudication due to Vascular Disease
* Diagnosed Diabetic Neuropathy
* Regular Cannabis use in past 6 months (more than once a week) OR once in last 2 weeks
* Regular opioid use in past week (Targin, Percocet, Tramadol) (Equivalent to Oxycodone 20 mg/day or more)
* Pregnancy or Lactating
* Ischemic heart disease
* Renal or hepatic failure
* History of psychiatric illness
* Cognitive impairment or inability to answer questions
* Known allergy to opioids
* Potential Loss to follow up

Where it's running

  • Hadassah Medical Center
    Jerusalem, Israel
    Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.