Transcranial Magnetic Stimulation to Help Heavy Cannabis Users See if They Use Less

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study uses left dorsolateral prefrontal cortex targeted iTBS to reduce neural reactivity to cannabis cues and lower cannabis use in adults aged 18-65 who currently use cannabis. It builds on prior data suggesting that enhancing cognitive control areas may dampen cue-driven craving and attention to drug cues. The protocol employs accelerated iTBS sessions to modulate brain circuits involved in salience and reward processing. The trial is conducted at Duke University Medical Center with NIDA collaboration, focusing on neuromodulation as a brain-based treatment option for cannabis use disorder. Participants must be cannabis users, meet safety criteria, and be able to complete all procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Males/non-pregnant females, 18-65 years old
* Current cannabis user
* Able to perform all study procedures

Exclusion Criteria:

* Regular use of other illicit drugs
* If medical history, physical and psychiatric examination, or laboratory tests performed during the screening process reveal any significant illness that the study physician deems contraindicated for study participation

Where it's running

• Duke University Medical Center
  Durham, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Tonisha Kearney-Ramos, PhD — Duke University
• Study coordinator: Tonisha Kearney-Ramos, PhD
• Email: tonisha.kearney-ramos@duke.edu
• Phone: 919-613-8153

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.