Predicting bipolar disorder relapse risk with multi-modal sentiment analysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project will enroll about 200 adults who meet DSM-5 criteria for bipolar disorder and are currently clinically stable. Researchers will collect multi-modal emotional data — such as voice recordings, facial expressions, and other behavioral signals — and fuse these features using sentiment-analysis and machine-learning methods. The goal is to build predictive models of recurrence risk based on these fused emotional features, leveraging prior cognitive neuroimaging and big-data work from the investigators. There is no interventional treatment; participants complete assessments and recordings during scheduled visits at the study site.

Why it matters

Who can join: the full rules

Patients group inclusion criteria:

* Patients who have previously met or currently meet the diagnostic criteria for bipolar disorder according to DSM-5, whose condition and treatment are currently stable, and who cooperate with the assessment;
* Age ≥18 years, \<65 years;
* Han Chinese ethnicity;
* Sufficient visual and auditory abilities to complete the necessary examinations for the study;
* Understanding the study content and signing the informed consent form. If the patient is unable to sign the informed consent form personally due to low education level or other reasons, it may be signed by a relative or guardian on their behalf.

exclusion criteria:

* The presence of intellectual disability or other conditions that significantly affect the patient's current mental state;
* the patient has a serious or unstable physical illness, including: neurological disorders (delirium, dementia, stroke, epilepsy, migraine, etc.), congestive heart failure, angina pectoris, myocardial infarction, arrhythmia, hypertension (including untreated or uncontrolled hypertension), malignant tumors, immunodeficiency, and blood glucose levels higher than 12 mmol/L; or other diseases that may interfere with the test assessment (abnormal indicators more than twice the normal value).

Healthy controls group inclusion criteria:

* Age ≥ 18 years, \< 65 years;
* Han Chinese ethnicity;
* Gender matched to the patient group;
* Sufficient visual and auditory ability to complete the necessary examinations for the study;
* Understanding of the study content and signing of informed consent;
* No family history of mental illness. exclusion criteria:
* Individuals with a mental disorder conforming to DSM-5, or those with suspicious mental symptoms but not meeting the diagnostic criteria;
* Individuals with severe physical illness that makes it difficult to complete the necessary examinations.

Where it's running

• Shanghai Mental Health Center
  Shanghai, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.