Predicting bipolar disorder relapse risk with multi-modal sentiment analysis

An Exploratory Study on the Prediction of Recurrence Risk of Bipolar Disorder Using Sentiment Analysis Technology Based on Multi-modal Feature Fusion

This project tests whether combining speech, facial, and other emotional signals can help predict relapse risk in adults with bipolar disorder.

Quick facts

• Study type: Observational
• Enrollment: 400 (estimated)
• Ages: 18 Years to 64 Years
• Sex: All
• Sponsor: Shanghai Mental Health Center (Academic / other)
• Locations: 1 site (Shanghai)
• Trial ID: NCT07573839 on ClinicalTrials.gov

What this trial studies

This observational project will enroll about 200 adults who meet DSM-5 criteria for bipolar disorder and are currently clinically stable. Researchers will collect multi-modal emotional data — such as voice recordings, facial expressions, and other behavioral signals — and fuse these features using sentiment-analysis and machine-learning methods. The goal is to build predictive models of recurrence risk based on these fused emotional features, leveraging prior cognitive neuroimaging and big-data work from the investigators. There is no interventional treatment; participants complete assessments and recordings during scheduled visits at the study site.

Who should consider this trial

Good fit: Adults aged 18–64 of Han Chinese ethnicity with a DSM-5 diagnosis of bipolar disorder who are clinically stable, able to hear and see adequately, and consenting to study procedures are eligible.

Not a fit: Patients with intellectual disability, serious or unstable physical or neurological illnesses, those unable to complete assessments, or those outside the specified age range or ethnicity are unlikely to benefit or be eligible.

Why it matters

Potential benefit: If successful, the work could enable earlier identification of patients at high risk of relapse so clinicians can offer preventative care sooner.

How similar studies have performed: Previous single- and dual-modality emotion-analysis studies have shown some promise in mood monitoring, but multi-modal feature-fusion approaches for predicting bipolar relapse remain relatively novel and not yet widely validated.

Eligibility criteria

Patients group inclusion criteria:

* Patients who have previously met or currently meet the diagnostic criteria for bipolar disorder according to DSM-5, whose condition and treatment are currently stable, and who cooperate with the assessment;
* Age ≥18 years, \<65 years;
* Han Chinese ethnicity;
* Sufficient visual and auditory abilities to complete the necessary examinations for the study;
* Understanding the study content and signing the informed consent form. If the patient is unable to sign the informed consent form personally due to low education level or other reasons, it may be signed by a relative or guardian on their behalf.

exclusion criteria:

* The presence of intellectual disability or other conditions that significantly affect the patient's current mental state;
* the patient has a serious or unstable physical illness, including: neurological disorders (delirium, dementia, stroke, epilepsy, migraine, etc.), congestive heart failure, angina pectoris, myocardial infarction, arrhythmia, hypertension (including untreated or uncontrolled hypertension), malignant tumors, immunodeficiency, and blood glucose levels higher than 12 mmol/L; or other diseases that may interfere with the test assessment (abnormal indicators more than twice the normal value).

Healthy controls group inclusion criteria:

* Age ≥ 18 years, \< 65 years;
* Han Chinese ethnicity;
* Gender matched to the patient group;
* Sufficient visual and auditory ability to complete the necessary examinations for the study;
* Understanding of the study content and signing of informed consent;
* No family history of mental illness. exclusion criteria:
* Individuals with a mental disorder conforming to DSM-5, or those with suspicious mental symptoms but not meeting the diagnostic criteria;
* Individuals with severe physical illness that makes it difficult to complete the necessary examinations.

Where this trial is running

Shanghai

• Shanghai Mental Health Center — Shanghai, China (Recruiting)

Conditions Bipolar Disorder; Healthy Control