Imaging bacterial infections using a radioactive tracer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the biodistribution and kinetics of a radioactive tracer called [18F]fluoropropyl-trimethoprim in human subjects. Participants with known or suspected bacterial infections will receive the tracer, which will be visualized using Positron Emission Tomography/Computed Tomography (PET/CT) imaging. The goal is to understand how the tracer accumulates in areas of active infection, which may improve diagnostic capabilities for bacterial infections. The study is interventional and is currently in Phase 1.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* At least 18 years of age
* Known or suspected bacterial infection, per clinical documentation of suspected infection (e.g. lab results, pathology results, physician progress notes, clinical symptoms of infection)
* Able to understand the investigational nature of this study and provide written informed consent in accordance with institutional and federal guidelines prior to study-specific procedures

Exclusion Criteria:

* Antibiotic therapy with trimethoprim within 48h of the baseline PET/CT scan
* Inability to tolerate imaging procedures, in the opinion of an investigator or treating physician
* Unstable or other severe medical or psychological comorbidities that would compromise the subject's safety or successful participation in the study, in the opinion of an investigator or treating physician
* Pregnant or breast feeding patients; a urine pregnancy test will be performed in women of child-bearing potential prior to \[18F\]F-TMP injection, to confirm non-pregnant status

Where it's running

• University of Pennsylvania
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Daniel Pryma, MD — University of Pennsylvania
• Study coordinator: Erin Schubert
• Email: erinschu@pennmedicine.upenn.edu
• Phone: 215-662-3041

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.