Comparative safety of antibiotics for common infections in pregnancy
Official title: Comparative Safety of Antibiotics for Common Bacterial Infections During Pregnancy
Funded at Brigham and Women's Hospital · NIH-11336396 · Data updated 2026-11-12
This project looks at which antibiotics are safest for babies when used to treat common infections in pregnant women.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 2, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $501,958 |
| NIH project number | 5R01HD107759-05 |
| Project ID | NIH-11336396 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant individuals who are being treated for bacterial infections and for whom antibiotics are being considered or prescribed.
✕Less likely to help
Pregnant patients using antibiotics with known higher risk profiles or those not eligible for the study’s data sources may not benefit.
What this research studies
Pregnant people often need antibiotics for infections like urinary tract infections and skin infections. The study aims to compare how different antibiotics affect pregnancy outcomes and newborn health, using data from real-world use and published evidence. Researchers will analyze safety signals such as birth defects, pregnancy loss, and neonatal problems to guide better choices for treating infections during pregnancy. The work focuses on balancing effective treatment for the mother with the safest possible outcomes for the baby.
Why it matters
Potential benefit: If successful, doctors could choose antibiotics that minimize risks to the fetus while still treating infections effectively.
How similar studies have gone: Previous research shows mixed safety signals; this project aims to clarify comparative safety across commonly used antibiotics in pregnancy.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Zhu, Yanmin — Brigham and Women's Hospital
- Study coordinator: Zhu, Yanmin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.