PACC1 in the body’s defense against bacterial infections and sepsis
Official title: PACC1 in host defense against bacterial infections and sepsis
Funded at Boston University Medical Campus · NIH-11368037 · Data updated 2026-11-12
A study exploring how a protein called PACC1 helps immune cells fight bacteria and prevent sepsis, with potential benefits for people at risk of severe infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 7, 2026 |
| Project end | March 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,618,716 |
| NIH project number | 1R01HL181357-01A1 |
| Project ID | NIH-11368037 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with bacterial infections or sepsis risk factors, and individuals who could provide insights through samples or future clinical trials.
✕Less likely to help
Patients without bacterial infections or sepsis may not directly benefit from this basic mechanistic study.
What this research studies
This project looks at how tissue-resident macrophages and other white blood cells use phagocytosis to control bacterial infections and how the PACC1 channel influences this process. Researchers will examine PACC1’s role in helping phagolysosomes work properly to kill bacteria in mice and human cells, especially during sepsis and pneumonia models. The work builds on preliminary findings that PACC1 affects sepsis risk and inflammatory responses, aiming to uncover why some individuals struggle to clear infections. By understanding PACC1’s function, the study may point to new strategies to reduce organ damage and mortality from bacterial sepsis.
Why it matters
Potential benefit: If successful, the research could lead to new approaches to prevent or treat sepsis by boosting the body’s ability to clear bacteria.
How similar studies have gone: Prior studies show that PACC1 influences macrophage function and infection outcomes in animal models, suggesting the approach is promising but still exploratory.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Bosmann, Markus — Boston University Medical Campus
- Study coordinator: Bosmann, Markus
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.