Understanding how certain brain tumors evade the immune system
Targeting oncogenic epigenetic mechanisms in IDHmut/ATRXloss Astrocytoma
This study is looking at how certain brain tumors called astrocytomas, which often affect younger adults, can avoid being attacked by the immune system, and it aims to find new ways to make treatments work better by understanding how these tumors interact with immune cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hugo W. Moser Res Inst Kennedy Krieger NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11043440 on NIH RePORTER |
What this research studies
This research focuses on astrocytomas, a type of brain tumor that often affects young to middle-aged adults. It aims to uncover the mechanisms by which these tumors, particularly those with specific genetic mutations, manage to escape the body's immune response. By studying the tumor microenvironment and the interactions between tumor cells and immune cells, the researchers hope to identify new therapeutic strategies that can enhance the effectiveness of immunotherapies. The approach includes analyzing cellular and molecular pathways that contribute to immune evasion in these tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older diagnosed with IDHmut/ATRXloss astrocytomas.
Not a fit: Patients with other types of brain tumors or those without the specific genetic mutations being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with specific types of astrocytomas, improving their chances of survival.
How similar studies have performed: Other research has shown promise in targeting immune evasion mechanisms in tumors, suggesting that this approach could be effective.
Where this research is happening
Baltimore, United States
- Hugo W. Moser Res Inst Kennedy Krieger — Baltimore, United States (Active)
Researchers
- Principal investigator: Li, Yunqing — Hugo W. Moser Res Inst Kennedy Krieger
- Study coordinator: Li, Yunqing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.