Evaluating cognitive function in patients with lower grade astrocytomas using advanced brain imaging techniques.
Official title: Multimodality Neuroimaging Evaluation of Cognitive Functioning in Lower Grade Astrocytoma
Funded at University of California, San Francisco · NIH-10910045 · Data updated 2026-11-12
This study is looking at how special brain scans can help us understand how lower grade astrocytomas affect thinking and memory in patients, with the hope of finding ways to improve their quality of life and support those who might struggle with cognitive issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 9, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $633,896 |
| NIH project number | 5R01CA273028-03 |
| Project ID | NIH-10910045 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with lower grade astrocytomas who may be experiencing cognitive impairments.
✕Less likely to help
Patients with other types of brain tumors or those without cognitive issues related to their condition may not benefit from this research.
What this research studies
This research investigates how advanced brain imaging techniques can assess cognitive functioning in patients with lower grade astrocytomas. By utilizing a combination of metabolic imaging, diffusion, perfusion, and functional MRI, the study aims to identify cognitive impairments and their relationship to tumor characteristics and treatment history. The goal is to provide a better understanding of how these tumors affect brain function and quality of life, potentially leading to targeted interventions for those at risk of cognitive decline.
Why it matters
Potential benefit: If successful, this research could lead to improved cognitive assessments and tailored interventions for patients with lower grade astrocytomas, enhancing their quality of life.
How similar studies have gone: Previous research has shown promising results using similar multimodal imaging approaches to assess cognitive function in brain tumor patients, indicating potential for success in this study.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Li, Yan — University of California, San Francisco
- Study coordinator: Li, Yan
Related research
Other NIH-funded projects on the same topics.
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Targeting epigenetic changes in IDH‑mutant, ATRX‑loss adult astrocytoma
Researchers are working to help the immune system better recognize and attack adult astrocytoma tumors that have IDH mutations and ATRX loss.
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Advanced brain MRI to understand thinking and memory in low-grade astrocytoma
This project uses advanced MRI scans to link brain changes with thinking and quality of life in people with lower-grade astrocytoma.
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Targeting tumor metabolism in IDH‑mutant grade 4 astrocytoma
People with IDH‑mutant grade 4 astrocytoma will get a short presurgery dose of a brain‑penetrant drug that blocks nucleotide metabolism to look for early effects on the tumor.
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Understanding how certain brain tumors evade the immune system
This study is looking at how certain brain tumors called astrocytomas, which often affect younger adults, can avoid being attacked by the immune system, and it aims to find new ways to make treatments work better by understanding how these tumors interact with immune cells.
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Targeting metabolic weaknesses in a type of brain tumor called IDH-mutant astrocytoma.
This study is looking for new ways to treat a type of brain tumor called IDH-mutant grade 4 astrocytomas by testing a special drug that targets the tumor's unique weaknesses, with the hope of killing the cancer cells while keeping healthy cells safe.
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Investigating a new treatment for recurrent brain tumors using a viral vector and a prodrug.
This study is looking at a new treatment for people with tough brain tumors called glioblastoma or anaplastic astrocytoma, using a special combination of therapies to see if it can help them live longer and fight their tumors better.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.