Targeting metabolic weaknesses in a type of brain tumor called IDH-mutant astrocytoma.
Targeting metabolic vulnerabilities in Astrocytoma, IDH-mutant, Grade 4
This study is looking for new ways to treat a type of brain tumor called IDH-mutant grade 4 astrocytomas by testing a special drug that targets the tumor's unique weaknesses, with the hope of killing the cancer cells while keeping healthy cells safe.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10911187 on NIH RePORTER |
What this research studies
This research focuses on developing new treatments for IDH-mutant grade 4 astrocytomas, a type of malignant brain tumor. The approach involves identifying specific metabolic vulnerabilities in tumor cells caused by genetic mutations, which can be targeted with specialized drugs. A phase 0 clinical trial will be conducted to test a new drug that affects nucleotide metabolism, aiming to selectively kill cancer cells while sparing healthy tissue. Patients will be closely monitored to assess how well the tumor responds to this treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with grade 4 astrocytomas that have IDH mutations.
Not a fit: Patients with other types of brain tumors or those without IDH mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted therapies for patients with IDH-mutant astrocytomas.
How similar studies have performed: Other research has shown promise in targeting metabolic vulnerabilities in cancer cells, suggesting this approach could be effective.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Batchelor, Tracy T — Brigham and Women's Hospital
- Study coordinator: Batchelor, Tracy T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.