Clinical trial Recruiting at 1 site Interventional Ages 18 to 45

Pre-surgery exercise to improve tendon, bone, and cartilage recovery after ACL rupture or patellar dislocation

Official title: A Study on the Effect of Exercise Rehabilitation on Bone Mineral Density, Reconstruction Ligament Tendon Bone Healing and Cartilage After ACL Rupture and Patellar Dislocation

Run by Peking University Third Hospital · NCT05924178 · Data updated 2026-11-12

This program will try pre-surgery exercise rehab to see if it improves tendon healing, bone density, cartilage health, and walking in people aged 18–40 with an ACL tear or patellar dislocation.

Quick facts

Study typeInterventional
Ages18 Years to 45 Years
SexAll
Enrollment60 (estimated)
SponsorPeking University Third Hospital
Academic / other
Locations1 site (Beijing)
StatusRecruiting
StartedJuly 10, 2023
Main results expectedJune 1, 2026
Study endsJune 1, 2026
Registry record updatedApril 15, 2026
Trial IDNCT05924178 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18–40 with a first-time unilateral ACL rupture or patellar dislocation confirmed by MRI who are scheduled for ACL reconstruction at the participating hospital.

Probably not a fit

Patients younger than 18 or older than 40, those with severe additional knee ligament injuries, or those with prior knee trauma are unlikely to be appropriate candidates for the interventions tested here.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers at Peking University Third Hospital will provide a course of preoperative exercise rehabilitation to young adults with ACL rupture or patellar dislocation who are scheduled for first-time unilateral ACL reconstruction. Participants will receive exercise rehabilitation or routine preoperative care, and outcomes will be measured before and after reconstruction. The protocol tracks knee bone mineral density, tendon–bone healing, bone tunnel changes, muscle strength, proprioception, gait characteristics, and cartilage changes using imaging and functional testing. Results will compare structural and functional recovery between the rehabilitation and routine-care groups.

Why it matters

Potential benefit: If successful, preoperative exercise rehabilitation could improve tendon–bone healing, help preserve knee bone density and cartilage, and speed functional recovery after ACL reconstruction.

How similar studies have gone: Some prior preoperative rehabilitation programs have shown functional improvements before and after ACL reconstruction, but effects specifically on tendon–bone healing, bone density, and cartilage remain less well established.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Age 18\~40 years old, diagnosed ACL rupture or Patellar Dislocation by MRI;
2. The first unilateral ligamenta reconstruction at our hospital;

Exclusion Criteria:

1. Be older than 40 years, or less than 18 years old
2. Severe injury to other knee ligaments
3. History of knee trauma

Where it's running

  • Peking University Third Hospital
    Beijing, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.