Pre-surgery exercise to improve tendon, bone, and cartilage recovery after ACL rupture or patellar dislocation
A Study on the Effect of Exercise Rehabilitation on Bone Mineral Density, Reconstruction Ligament Tendon Bone Healing and Cartilage After ACL Rupture and Patellar Dislocation
This program will try pre-surgery exercise rehab to see if it improves tendon healing, bone density, cartilage health, and walking in people aged 18–40 with an ACL tear or patellar dislocation.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | Peking University Third Hospital Academic / other |
| Locations | 1 site (Beijing) |
| Trial ID | NCT05924178 on ClinicalTrials.gov |
What this trial studies
Researchers at Peking University Third Hospital will provide a course of preoperative exercise rehabilitation to young adults with ACL rupture or patellar dislocation who are scheduled for first-time unilateral ACL reconstruction. Participants will receive exercise rehabilitation or routine preoperative care, and outcomes will be measured before and after reconstruction. The protocol tracks knee bone mineral density, tendon–bone healing, bone tunnel changes, muscle strength, proprioception, gait characteristics, and cartilage changes using imaging and functional testing. Results will compare structural and functional recovery between the rehabilitation and routine-care groups.
Who should consider this trial
Good fit: Adults aged 18–40 with a first-time unilateral ACL rupture or patellar dislocation confirmed by MRI who are scheduled for ACL reconstruction at the participating hospital.
Not a fit: Patients younger than 18 or older than 40, those with severe additional knee ligament injuries, or those with prior knee trauma are unlikely to be appropriate candidates for the interventions tested here.
Why it matters
Potential benefit: If successful, preoperative exercise rehabilitation could improve tendon–bone healing, help preserve knee bone density and cartilage, and speed functional recovery after ACL reconstruction.
How similar studies have performed: Some prior preoperative rehabilitation programs have shown functional improvements before and after ACL reconstruction, but effects specifically on tendon–bone healing, bone density, and cartilage remain less well established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 18\~40 years old, diagnosed ACL rupture or Patellar Dislocation by MRI; 2. The first unilateral ligamenta reconstruction at our hospital; Exclusion Criteria: 1. Be older than 40 years, or less than 18 years old 2. Severe injury to other knee ligaments 3. History of knee trauma
Where this trial is running
Beijing
- Peking University Third Hospital — Beijing, China (Recruiting)
Study contacts
- Study coordinator: Shuang Ren
- Email: xixishuang123@126.com
- Phone: 17610252992
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.