Quadriceps tendon vs peroneus longus tendon grafts for ACL reconstruction
Official title: A Prospective Randomized Clinical Trial Comparing Quadriceps Tendon and Peroneus Longus Tendon Autografts in Anterior Cruciate Ligament Reconstruction: Clinical, Functional, and Gait Analysis Outcomes
Run by Acibadem University · NCT07671729 · Data updated 2026-11-12
This randomized trial tests whether using a quadriceps tendon autograft works as well as a peroneus longus tendon autograft for ACL reconstruction in adults, looking at knee function and donor-site effects.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Acibadem University Academic / other |
| Locations | 1 site (Istanbul, Besiktas) |
| Status | Recruiting |
| Started | May 1, 2026 |
| Main results expected | May 2027 |
| Study ends | December 2027 |
| Registry record updated | June 26, 2026 |
| Trial ID | NCT07671729 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–50 with an ACL rupture scheduled for primary ACL reconstruction.
✕Probably not a fit
Patients who do not experience the expected graft-related differences or who have factors limiting graft choice may receive limited benefits.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with ACL injuries undergoing primary ACL reconstruction are randomly assigned to receive either a quadriceps tendon autograft or a peroneus longus tendon autograft. The study follows participants for 12 months, assessing knee function, return-to-sport outcomes, ankle strength and function, and gait metrics. Outcomes include donor-site morbidity and overall knee stability after surgery. Data collection includes clinical exams and standardized functional scores at 6 and 12 months postoperatively. This trial aims to clarify differences in graft performance and potential complications between the two graft options.
Why it matters
Potential benefit: If successful, the trial could help surgeons choose a graft with better balance of knee function and donor-site morbidity.
How similar studies have gone: Prior ACL graft comparisons show varying results by graft type, making this direct quadriceps vs peroneus longus comparison valuable but not yet proven.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients diagnosed with anterior cruciate ligament rupture * Patients scheduled for primary anterior cruciate ligament reconstruction * Age between 18 and 50 years * Ability to provide informed consent * Willingness to comply with postoperative rehabilitation and follow-up evaluations Exclusion Criteria: * Previous ligament reconstruction surgery on the affected knee * Multi-ligament knee injuries requiring additional ligament reconstruction * Severe osteoarthritis of the knee * Revision anterior cruciate ligament reconstruction * Neuromuscular disorders affecting lower extremity function * Active infection * Inability to comply with follow-up protocol
Where it's running
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Acibadem Fulya Hospital, Sport Medicine Center
Istanbul, Besiktas, Turkey (Türkiye) Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.