Clinical trial Recruiting at 1 site Interventional Ages 18 to 50

Quadriceps tendon vs peroneus longus tendon grafts for ACL reconstruction

Official title: A Prospective Randomized Clinical Trial Comparing Quadriceps Tendon and Peroneus Longus Tendon Autografts in Anterior Cruciate Ligament Reconstruction: Clinical, Functional, and Gait Analysis Outcomes

Run by Acibadem University · NCT07671729 · Data updated 2026-11-12

This randomized trial tests whether using a quadriceps tendon autograft works as well as a peroneus longus tendon autograft for ACL reconstruction in adults, looking at knee function and donor-site effects.

Quick facts

Study typeInterventional
Ages18 Years to 50 Years
SexAll
Enrollment60 (estimated)
SponsorAcibadem University
Academic / other
Locations1 site (Istanbul, Besiktas)
StatusRecruiting
StartedMay 1, 2026
Main results expectedMay 2027
Study endsDecember 2027
Registry record updatedJune 26, 2026
Trial IDNCT07671729 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18–50 with an ACL rupture scheduled for primary ACL reconstruction.

Probably not a fit

Patients who do not experience the expected graft-related differences or who have factors limiting graft choice may receive limited benefits.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with ACL injuries undergoing primary ACL reconstruction are randomly assigned to receive either a quadriceps tendon autograft or a peroneus longus tendon autograft. The study follows participants for 12 months, assessing knee function, return-to-sport outcomes, ankle strength and function, and gait metrics. Outcomes include donor-site morbidity and overall knee stability after surgery. Data collection includes clinical exams and standardized functional scores at 6 and 12 months postoperatively. This trial aims to clarify differences in graft performance and potential complications between the two graft options.

Why it matters

Potential benefit: If successful, the trial could help surgeons choose a graft with better balance of knee function and donor-site morbidity.

How similar studies have gone: Prior ACL graft comparisons show varying results by graft type, making this direct quadriceps vs peroneus longus comparison valuable but not yet proven.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients diagnosed with anterior cruciate ligament rupture
* Patients scheduled for primary anterior cruciate ligament reconstruction
* Age between 18 and 50 years
* Ability to provide informed consent
* Willingness to comply with postoperative rehabilitation and follow-up evaluations

Exclusion Criteria:

* Previous ligament reconstruction surgery on the affected knee
* Multi-ligament knee injuries requiring additional ligament reconstruction
* Severe osteoarthritis of the knee
* Revision anterior cruciate ligament reconstruction
* Neuromuscular disorders affecting lower extremity function
* Active infection
* Inability to comply with follow-up protocol

Where it's running

  • Acibadem Fulya Hospital, Sport Medicine Center
    Istanbul, Besiktas, Turkey (Türkiye)
    Recruiting

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.