LSD for people with alcohol use disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a Phase 2, randomized, double-blind trial comparing LSD to an active placebo in adults with moderate to severe DSM-5 alcohol use disorder who intend to stop or reduce drinking. Participants must be at least 25 years old and recently detoxified or abstinent, and they receive two administrations during the blinded phase with follow-up assessments up to six months; an open-label phase with additional assessments follows. Outcome measures include self-report drinking measures, standardized questionnaires (e.g., TLFB, OCDS, SIP-2R), biological alcohol markers, and adverse event monitoring. The trial updates and extends historical single-dose LSD research by using modern diagnostics, repeated dosing, biological verification of alcohol use, and blinded controls.

Why it matters

Who can join: the full rules

Key inclusion criteria:

* Age ≥ 25 years
* Participants must meet the DSM-5 criteria for a moderate to severe alcohol use disorder and must intend to stop or decrease their drinking for at least the duration of the study
* Participants must have underwent an alcohol detoxification within the 60 days prior to screening or, in cases where no detoxification is necessary, must have been abstinent for at least 14 days.
* A minimum of 4 HDD within the last 30 days before detoxification or cessation of alcohol use (a HDD is defined as 5 or more standard drinks per day for a man and 4 drinks for a woman; a standard drink is defined as 12 g of alcohol)

Key exclusion criteria:

* Significant alcohol withdrawal symptoms at screening
* Participating or starting in any formal treatment for AUD from visit 1 until completion of the double-blind phase
* Treatment with disulfiram during the study
* Past or present diagnosis of a DSM-5 psychotic or bipolar disorder in subjects or first-degree relatives
* Current suicidality or history of a serious suicide attempt

Where it's running

• University Hospital of Psychiatry, University of Basel
  Basel, Switzerland Recruiting
• University Hospital of Psychiatry, University of Bern
  Bern, Switzerland Recruiting

Study contacts

• Study coordinator: Felix Müller, PD Dr. med.
• Email: felix.mueller@upk.ch
• Phone: +41 (0)61 325 5111

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Imaging Mitochondrial Complex-I and Brain Metabolism in Alcohol Use Disorder

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• Endurance exercise to see if it lowers alcohol use in adults with AUD and ALD

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• Do beverage cues drive craving in adults with AUD

  In adults with alcohol use disorder, this study tests whether different non-alcoholic beverage cues can trigger cravings differently when people see and smell them without drinking.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07788716

• Semaglutide for Alcohol Use Disorder and Obesity: Testing 1.0 mg and 2.0 mg vs Placebo

  We’re testing two doses of semaglutide to see if they reduce alcohol craving and use in adults with alcohol use disorder and obesity compared with placebo.

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• TRIS: a mobile app with breathalyzer to support sobriety in alcohol use disorder

  A smartphone app with a connected breathalyzer tests for abstinence and uses small financial incentives to encourage sobriety for adults with AUD in Brazil.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT07735585

• Body-focused mindfulness added to inpatient alcohol use disorder treatment

  This trial tests whether a body-focused mindfulness program can help people with alcohol use disorder feel more connected to their bodies and reduce cravings while in inpatient care.

  Recruiting Medical University of Warsaw · Warsaw, Mazovian · NCT07706660

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.