Condition

Colo-rectal Cancer clinical trials and research

• 30Clinical trials
• 12Countries

Newest Colo-rectal Cancer clinical trials

All recruiting trials (30)

• Prehabilitation before high-risk cancer surgery

  This trial tests a multidisciplinary prehabilitation program to see if it helps adults with cancer recover better after major abdominal surgery.

  Recruiting Fox Chase Cancer Center · Philadelphia, Pennsylvania · NCT07638410

• Personal cancer risk testing using genetic, blood, and tumor monitoring

  This project will test whether combining genetic testing, blood-based analyses, and tumor tissue checks can identify personal cancer risk and detect early recurrence in adults with breast, ovarian, colorectal, melanoma, or certain non-small cell lung cancers.

  Recruiting Fondazione del Piemonte per l'Oncologia · Candiolo, Turin · NCT07469709

• Liquid biopsy and machine learning to detect early colorectal cancer, advanced adenomas, Lynch-related cancers, and residual disease

  This project will test a blood-based liquid biopsy that uses microRNA signals and machine learning to detect colorectal cancer, advanced adenomas, Lynch-associated cancers, and molecular residual disease in people who have a colonoscopy.

  Recruiting San Raffaele University · Milan, Lombardy and 3 other locations · NCT07450612

• Colorectal Cancer Screening Outreach for Better Adherence

  This trial tests a bundled messaging approach to help adults at risk complete colorectal cancer screening.

  Recruiting Yale University · New Haven, Connecticut · NCT07345676

• Blood-based delta-HLD methylation test for detecting colorectal cancer

  This will try a blood-based delta-HLD methylation test to see if it can detect colorectal cancer in people scheduled for colonoscopy or colorectal surgery.

  Recruiting Epiliquid Holding, Inc · Mendoza · NCT07148297

• MBRC-201 dose-finding and safety in advanced metastatic solid tumors

  We will test different doses of an antibody-drug conjugate called MBRC-201 in adults whose advanced metastatic cancers (including prostate, breast, colorectal, lung, and pancreatic cancer) have not responded to standard treatments.

  Recruiting at 7 sites Phase 1/2 MBrace Therapeutics · San Francisco, California and 6 other locations · NCT07145255

• Low-dose trifluridine/tipiracil plus bevacizumab for metastatic colorectal cancer

  This will try a lower-dose trifluridine/tipiracil plus bevacizumab regimen for people with metastatic colorectal cancer who have progressed after at least two prior treatments.

  Recruiting at 2 sites Phase 2 Ruijin Hospital · Sanming and 1 other locations · NCT07085169

• ALX2004 for advanced or metastatic EGFR-expressing solid tumors

  This trial will test ALX2004, an antibody-drug conjugate that targets EGFR, in people with advanced or metastatic non-small cell lung, head and neck, esophageal, or colorectal cancer to see if it is safe and shows tumor activity.

  Recruiting at 11 sites Phase 1 ALX Oncology Inc. · La Jolla, California and 11 other locations · NCT07085091

• Cemiplimab alone or with Fianlimab or REGN7075 after surgery and chemo in colorectal cancer with minimal residual disease

  This study tests whether cemiplimab alone or in combination with fianlimab or REGN7075 can help prevent colorectal cancer from returning in adults who are ctDNA-positive after standard treatment.

  Recruiting at 13 sites Phase 2 NSABP Foundation Inc · Gainesville, Florida and 12 other locations · NCT07058012

• Natera blood-based colorectal cancer screening for average-risk adults

  This will test whether Natera's blood-based colorectal cancer screening can find cancer in average-risk adults who are planning a colonoscopy.

  Recruiting Natera, Inc. · Austin, Texas · NCT07046585

• Cadonilimab plus an anti-angiogenic drug for metastatic dMMR/MSI-H colorectal cancer

  We will try cadonilimab together with an anti-angiogenic drug in people with metastatic dMMR/MSI‑H colorectal cancer, including those who are new to PD‑1/PD‑L1 therapy and those who have had it before.

  Recruiting Phase 2 Fudan University · Shanghai, China · NCT07003022

• Observational study on early-onset colorectal cancer

  This study looks at young adults with colorectal cancer to learn more about the disease and find new treatment options.

  Recruiting Niguarda Hospital · Milan, Milano · NCT06965335

• Training program for patients with permanent colostomies to improve self-efficacy

  This study tests a training program for people with permanent colostomies to see if it helps them feel more confident and better manage their condition.

  Recruiting Cukurova University · Adana, Yüreğir · NCT06905925

• Shield post-approval follow-up for colorectal cancer screening

  This project will see if the Shield blood test reliably detects colorectal cancer or advanced polyps when used as a second-round screen in average-risk people aged 45–81, using colonoscopy as the comparison.

  Recruiting at 58 sites Guardant Health, Inc. · Chandler, Arizona and 68 other locations · NCT06880055

• Creating organoids from colorectal tumors and liver metastases

  This study is trying to create mini versions of colorectal tumors and their liver spread to see how certain genes work and find new ways to treat cancer.

  Recruiting Regina Elena Cancer Institute · Rome · NCT06787625

• Investigating how blood vessel invasion affects cancer spread in colorectal cancer

  This study is trying to see if cancer spreading through blood vessels makes colorectal cancer worse than if it spreads through lymph nodes by looking at tissue samples from patients who had surgery.

  Recruiting Imperial College London · Basingstoke, Hampshire · NCT06646341

• AI-assisted risk-guided perioperative care for colorectal cancer surgery

  This trial will test whether AI-assisted risk assessment helps surgeons better predict complications and guide perioperative care for adults undergoing colorectal cancer surgery.

  Recruiting at 6 sites Zealand University Hospital · Aalborg and 7 other locations · NCT06645015

• Using synbiotics to prevent mucositis in colorectal cancer patients undergoing chemotherapy

  This study is testing if taking synbiotics can help prevent mouth sores and diarrhea in people with colorectal cancer who are starting chemotherapy.

  Recruiting Federal University of Minas Gerais · Belo Horizonte, Minas Gerais · NCT06576986

• Stereotactic Ablative Radiotherapy for metastatic cancer treatment

  This study tests if starting stereotactic ablative radiotherapy right away helps people with newly diagnosed metastatic lung, colorectal, or prostate cancer live longer compared to waiting three months to start treatment.

  Recruiting Phase 3 Roswell Park Cancer Institute · Buffalo, New York · NCT06563388

• Comparing new app-based health education to traditional methods for bowel preparation before colonoscopy

  This study is testing if a new app for health education can help people better prepare for a colonoscopy compared to traditional methods.

  Recruiting National Taiwan University Hospital · Hsinchu · NCT06560671

• Using tislelizumab to treat cancer patients with detectable tumor DNA after surgery

  This study is testing if the immunotherapy drug tislelizumab can help cancer patients who have had surgery and still have traces of tumor DNA in their blood to avoid a relapse.

  Recruiting Phase 3 Gustave Roussy, Cancer Campus, Grand Paris · Villejuif, Val De Marne · NCT06332274

• Platform program for evaluating treatments in metastatic HER2-positive breast cancer

  This study is testing different new treatments for people with advanced HER2-positive breast cancer to see which ones work best before moving them to larger trials.

  Recruiting at 5 sites Phase 1/2 QuantumLeap Healthcare Collaborative · Birmingham, Alabama and 9 other locations · NCT05868226

• Improving colorectal cancer screening access through community health centers

  This study is trying to find out how to make it easier for people aged 45 and older to get screened for colorectal cancer at community health centers in Massachusetts.

  Recruiting at 4 sites Massachusetts General Hospital · Boston, Massachusetts and 3 other locations · NCT05524428

• Characteristics of Colon Cancer in Young Patients

  This study looks at how colon cancer affects younger patients differently based on their age and gender to see what factors might influence their recovery.

  Recruiting Seoul National University Bundang Hospital · Seongnam-si, Gyeonggi-do · NCT05365412

• Evaluating a new single port robotic approach for colorectal surgery

  This study is testing a new single port robotic surgery method for colorectal procedures to see if it's safer and works better than the traditional multi-port approach.

  Recruiting University of California, Davis · Sacramento, California · NCT05321134

• Engineered TILs and CAR-TILs for treating advanced solid tumors

  This study is testing a new way to treat advanced solid tumors by using specially modified immune cells from patients to see if they can better fight the cancer.

  Recruiting Phase 1 Second Affiliated Hospital of Guangzhou Medical University · Guangzhou · NCT04842812

• Registry for advanced endoscopic procedures

  This study is collecting information from patients who are having advanced endoscopy procedures for gastrointestinal diseases to see how well these treatments work and improve patient care.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT04117100

• Improving MRI accuracy for early-stage rectal cancer treatment

  This study tests a new way for doctors to read MRIs to see if it can help more people with early-stage rectal cancer avoid major surgery and keep their bowel function.

  Recruiting Imperial College London · Reading, Berkshire and 22 other locations · NCT04103372

• Infusion of checkpoint inhibitors and chemotherapy for advanced solid tumors

  This study is testing if giving a mix of immune therapy and chemotherapy directly to tumors helps people with advanced cancers feel better compared to the usual way of giving these treatments.

  Recruiting Phase 2/3 Second Affiliated Hospital of Guangzhou Medical University · Guanzhou, Guangdong · NCT03755739

• Pressurized Chemotherapy for High Risk Colon Cancer Patients

  This study is testing a new type of chemotherapy for patients with high-risk colon cancer to see if it can help prevent cancer from coming back after surgery and standard treatment.

  Recruiting Phase 2 Odense University Hospital · Odense · NCT03280511

Related topics

Quick answers

How many Colo-rectal Cancer clinical trials are recruiting right now?

30, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (11 trials), Italy (4 trials), China (4 trials), Denmark (2 trials), United Kingdom (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1/2: 2, Phase 1: 2, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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