Condition

Acute Stroke clinical trials and research

• 26Clinical trials
• 24NIH research projects
• 20Countries

Newest Acute Stroke clinical trials

All recruiting trials (26)

• Unimanual vs. Bimanual Motor Skill Learning After Stroke

  The study tests whether people with acute or chronic stroke, as well as healthy controls, can learn and remember a complex motor task using one hand or both, with robotic devices REAplan and Dextrain.

  Recruiting University Hospital of Mont-Godinne · Yvoir, Namur · NCT07826832

• Sarcopenia in older adults with acute ischemic stroke

  This study tests how common sarcopenia is in people 50 and older after an acute ischemic stroke and whether having sarcopenia at hospital admission is linked to worse outcomes three months later.

  Recruiting University Clinical Hospital na V.V.Vinogradov (branch of RUDN university na Patrice Lumumba) · Moscow · NCT07764172

• Low-Field MRI in Emergency Stroke Care

  This study tests whether a portable low-field MRI can help detect acute stroke in patients arriving with suspected stroke.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT07702968

• Best Care for Acute Stroke in General Wards

  A nurse-led program called BEST CARE ICTUS_HC is tested in hospitals without Stroke Units to see if it reduces stroke complications and helps recovery after an acute ischemic or hemorrhagic stroke.

  Recruiting University of Malaga · Antequera, Málaga and 3 other locations · NCT07627399

• Continuous Dual Aspiration with the Zoom System for Acute Ischemic Stroke

  This trial will try using the Zoom aspiration system with a continuous dual aspiration technique to remove clots in adults with acute ischemic stroke.

  Recruiting at 25 sites Imperative Care, Inc. · Huntsville, Alabama and 24 other locations · NCT07491952

• Using the mSOAR score to predict early death after an acute stroke

  This project will try the mSOAR score to see if it can predict early death in adults admitted with acute stroke at Sohag University Hospitals.

  Recruiting Sohag University · Sohag · NCT07355881

• Isolated versus synergetic muscle facilitation to improve arm function after acute stroke

  This project will test whether isolated or synergetic muscle facilitation improves arm function in people with an acute middle cerebral artery stroke.

  Recruiting Cairo University · Cairo · NCT07273201

• Mirror therapy to improve hand function after acute stroke

  This trial will test whether adding mirror therapy to usual physiotherapy helps people with a recent stroke regain arm and hand movement, reduce spasticity, and increase range of motion.

  Recruiting Riphah International University · Malakand, KPK · NCT07204067

• Dimephosphon® for recovery after acute ischemic stroke.

  This trial will test whether Dimephosphon® given 24–72 hours after stroke onset helps adults with moderate acute ischemic stroke recover better than a placebo.

  Recruiting at 5 sites Phase 3 Tatchempharmpreparaty, JSC · Vsevolozhsk, Leningradskaya Oblast' and 5 other locations · NCT07167550

• Using MRI to speed diagnosis and care for adults with acute stroke in the emergency room

  We will test whether a streamlined MRI protocol helps doctors diagnose and treat adults with acute stroke faster in the emergency department.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT07138768

• Choosing rehabilitation care after an acute stroke: what matters to patients

  This project asks people who recently had an acute stroke about their health and preferences to see if certain factors influence which rehabilitation option they choose.

  Recruiting National Taiwan University Hospital · Taipei · NCT07089095

• Early personalized nutrition to reduce one-month mortality after acute stroke

  This trial tests if giving personalized nutritional support within 2 days of an acute stroke can reduce the risk of dying within one month.

  Recruiting at 11 sites University Hospital, Angers · Chesnay, Yvelines and 11 other locations · NCT07065929

• AI-guided personalized rehabilitation to improve upper-limb recovery after stroke

  This project tests whether an explainable AI system can predict recovery and recommend tailored rehab (usual care alone or plus acupuncture, robotic training, or NMES) for people aged 65–80 who had a first-time unilateral stroke 1–6 months earlier.

  Recruiting Chinese University of Hong Kong · Hong Kong, Sha Tin · NCT06828679

• Comparing treatments for acute intracerebral hemorrhage to prevent secondary brain injury

  This study is testing if giving certain medications early can help prevent further brain damage in people with a type of bleeding in the brain.

  Recruiting Phase 3 The George Institute · Sydney, New South Wales and 1 other locations · NCT06763055

• Effects of chin tuck exercises on swallowing in stroke patients

  This study tests if doing chin tuck exercises can help stroke patients with swallowing problems feel better and improve their quality of life compared to standard therapy.

  Recruiting National Taiwan University Hospital · Taipei · NCT06674356

• Investigating body composition's impact on stroke recovery

  This study tests how body composition affects recovery in stroke patients to see if it can help improve their rehabilitation plans.

  Recruiting Centre Hospitalier Régional d'Orléans · Orléans · NCT06589297

• Observing recovery patterns in stroke survivors

  This study looks at how different factors right after a stroke affect how well survivors recover over time.

  Recruiting IRCCS San Raffaele · Milan · NCT06465758

• Using non-immunogenic staphylokinase to restore blood flow after ischemic stroke

  This will test whether a new clot-busting drug called non-immunogenic staphylokinase is safe and works as well as alteplase for adults 18–85 treated for acute ischemic stroke.

  Recruiting National Society for Neurosonology and Cerebral Circulation · Saint Petersburg · NCT05697575

• Treatment for Acute Ischemic Stroke using DM199

  This study is testing if a new treatment called DM199 can help people with moderate acute ischemic stroke recover better when given soon after their symptoms start.

  Recruiting at 78 sites Phase 2/3 DiaMedica Therapeutics Inc · Fairhope, Alabama and 85 other locations · NCT05065216

• Evaluating choking risk in stroke patients using laryngeal ultrasound

  This study tests if using a safe ultrasound can help doctors see how well stroke patients can swallow and if they are at risk of choking or getting pneumonia.

  Recruiting National Taiwan University Hospital · Taipei, None Selected · NCT04874454

• Analyzing non-coding RNA in patients with acute ischemic stroke

  This study is trying to see if certain types of non-coding RNA in the blood can help doctors better detect and understand the outcomes of patients who have had an acute ischemic stroke.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu · NCT04175691

• Comparing sedation methods for patients with acute ischemic stroke undergoing thrombectomy

  This study is testing two different sedation methods during a procedure for patients with acute ischemic stroke to see which one helps improve blood flow and recovery.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT03737786

• Understanding the connection between heart and brain in acute ischemic stroke

  This study looks at how heart problems can cause strokes and aims to improve the way doctors diagnose heart attacks in stroke patients to help them get better treatment.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern, Canton of Bern · NCT03720522

• Using a special device to improve outcomes for stroke patients during helicopter transport

  This study is testing whether a special device that uses blood pressure cuffs can help protect the brains of stroke patients during their helicopter transport to a hospital.

  Recruiting University of Iowa · Iowa City, Iowa · NCT03481205

• Registry connecting stroke survivors with research opportunities

  This study connects stroke survivors with research opportunities to help find new treatments that can improve their recovery.

  Recruiting University of California, San Francisco · San Francisco, California · NCT03318432

• Rehabilitation using a wearable robot for stroke recovery

  This study is testing if using a wearable robot for rehabilitation can help people who have had a stroke recover better and improve their movement and balance.

  Recruiting University of Maryland, Baltimore · Baltimore, Maryland · NCT02369770

NIH-funded research (24)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• In-bed wearable rehab robot to help stroke survivors recover movement

  A wearable robotic device will be developed to help adults who recently had an acute stroke regain movement while still in the hospital.

  NIH research Rehabtek, LLC · Linthicum Heights, UNITED STATES · NIH-11419615

• When people are most at risk of another stroke after a minor stroke or TIA

  Researchers are combining past trial data to find the timing of highest risk for a second stroke after a minor stroke or TIA so treatments can be better timed.

  NIH research University of Chicago · Chicago, United States · NIH-11416242

• Improving Participation after Stroke: Self-Management Rehab for Sub-Acute Stroke

  A doctor- and patient-friendly program delivered virtually helps people who recently had a stroke feel more confident, stay active at home, and improve quality of life.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-11381081

• Targeting a brain inflammation regulator to protect cells after a stroke

  Aims to test a new approach that tampers with a key brain cell regulator to reduce inflammation and protect brain tissue after a stroke, potentially lowering disability.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11380954

• Predicting brain tissue outcome after acute stroke using AI

  A researchers at Stanford are testing an AI system that uses brain scans and clinical data to predict which parts of the brain will recover after an acute stroke and how treatment might help.

  NIH research Stanford University · Stanford, United States · NIH-11378453

• Helping brain recovery for people with severe paralysis after a recent stroke

  This project builds a wearable in-bed robot to give gentle movement and sensory training to adults with severe weakness right after a stroke.

  NIH research Rehabtek, LLC · Linthicum Heights, UNITED STATES · NIH-11365604

• Language recovery after stroke: how people regain communication skills and how to help

  A Johns Hopkins team is studying how people recover language after a left-hemisphere stroke and what helps them regain reading, spelling, and understanding spoken and written language.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11362568

• Faster, better-coordinated stroke care for rural communities

  This project uses computer models to find smarter ways for emergency responders and hospitals to get faster stroke treatment to people in rural areas.

  NIH research Duke University · Durham, United States · NIH-11289361

• Portable low-field brain MRI for emergency stroke care

  This project will bring a small, movable MRI to the bedside and in ambulances to get quick brain scans for people with suspected acute stroke.

  NIH research Yale University · New Haven, United States · NIH-11241141

• AI to Predict Memory and Thinking Problems After Stroke

  This project uses artificial intelligence to help doctors understand which stroke patients might develop memory and thinking problems, so they can receive better care.

  NIH research Emory University · Atlanta, United States · NIH-11230049

• Improving Stroke Treatment Decisions with AI

  This project is developing an advanced computer system to help doctors make faster and better decisions for patients experiencing a sudden stroke.

  NIH research Stanford University · Stanford, United States · NIH-11177055

• Virtual program to help stroke survivors get back to home, work, and community activities

  This project offers a virtual self-management program for people recovering from a recent stroke to boost confidence, daily activity, and community participation.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-11144974

• Boosting surface brain vessel blood flow during large strokes

  This project tests treatments to keep tiny surface brain vessels open during a major ischemic stroke to help people—especially those with chronic high blood pressure—save more brain tissue.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11057594

• Improving stroke care access for rural communities

  This study is looking at ways to improve emergency care for people in rural areas who have strokes, by finding the best ways for ambulance services to get patients to specialized hospitals quickly and efficiently.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11015886

• Portable MRI technology for diagnosing acute stroke

  This study is working on a new, portable MRI machine that can be used right at the bedside of patients having a stroke, so doctors can quickly and accurately diagnose the problem and start treatment faster.

  NIH research Yale University · New Haven, United States · NIH-11013870

• Understanding how neutrophils contribute to brain damage after a stroke

  This study is looking at how certain white blood cells called neutrophils affect inflammation and brain damage after a stroke, with the goal of finding new ways to help stroke patients recover better.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10996186

• Understanding how to prevent second strokes after the first one

  This study is looking at how often people have another stroke after a minor stroke or TIA, and it aims to create a helpful tool to predict the risk of another stroke, which could lead to better treatments for patients like you.

  NIH research University of Chicago · Chicago, United States · NIH-10993146

• Using AI to predict cognitive impairment after a stroke

  This study is looking at how artificial intelligence can help doctors understand which stroke patients might have trouble with thinking and memory after their stroke, so they can get the right support to recover better.

  NIH research Emory University · Atlanta, United States · NIH-10985212

• Using AI to predict outcomes in acute stroke patients

  This study is looking to improve how doctors quickly decide on the best treatment for stroke patients by using smart computer technology to combine brain scans and medical information, aiming to help patients get better care faster and safer.

  NIH research Stanford University · Stanford, United States · NIH-10900566

• Using blood tests to help diagnose stroke faster in African Americans

  This study is looking at a new blood test that uses RNA to help doctors quickly and accurately diagnose strokes, especially in African American patients, so they can get the right treatment faster.

  NIH research Morehouse School of Medicine · Atlanta, United States · NIH-10866379

• Improving self-management and rehabilitation for people recovering from stroke

  This study is testing a program called IPASS-R that helps people recovering from a stroke feel more confident and improve their daily activities through virtual sessions, and it will see how well this program works compared to a general health self-management program.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-10856613

• Improving sleep for stroke patients during rehabilitation

  This study is looking at ways to help people recovering from strokes get better sleep, which is really important for healing, by reducing nighttime disruptions and checking for sleep problems, so they can feel stronger and recover more effectively.

  NIH research University of Chicago · Chicago, United States · NIH-10763378

• Improving recovery for stroke survivors with severe paralysis

  This study is testing a new wearable robot designed to help stroke survivors with severe arm and leg weakness recover better while they are still in bed, by providing important training to improve their movement and brain function early on.

  NIH research Rehabtek, LLC · Linthicum Heights, UNITED STATES · NIH-10577199

• Understanding how different brain pathways affect movement after a stroke

  This study is looking at how different pathways in the brain can help people recover their movement after a stroke, especially for those with more serious challenges, so that rehab can be customized to fit each person's needs and help them get back on their feet better.

  NIH research University of Texas Rio Grande Valley · Edinburg, United States · NIH-10439241

Related topics

Quick answers

How many Acute Stroke clinical trials are recruiting right now?

26, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (6 trials), France (3 trials), Egypt (3 trials), Taiwan (3 trials), Russia (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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