Understanding how to prevent second strokes after the first one
Official title: Kinetic analysis of acute stroke secondary prevention trials: Insights from combined datasets guiding future trial design
Funded at University of Chicago · NIH-10993146 · Data updated 2026-11-12
This study is looking at how often people have another stroke after a minor stroke or TIA, and it aims to create a helpful tool to predict the risk of another stroke, which could lead to better treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $361,097 |
| NIH project number | 5R61NS135583-02 |
| Project ID | NIH-10993146 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently suffered a minor stroke or TIA.
✕Less likely to help
Patients who have not experienced a stroke or TIA may not receive any benefit from this research.
What this research studies
This research investigates the patterns of stroke recurrence following an initial minor stroke or transient ischemic attack (TIA). By analyzing data from previous clinical trials, the study aims to develop a kinetic model that predicts the risk of having another stroke over time. This model will help identify different biological mechanisms involved in stroke recurrence and how they respond to various treatments. Patients who have experienced a minor stroke or TIA may benefit from insights gained through this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing second strokes in patients who have already experienced a minor stroke or TIA.
How similar studies have gone: Previous studies have shown success in understanding stroke recurrence patterns, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Brorson, James R. — University of Chicago
- Study coordinator: Brorson, James R.
Related research
Other NIH-funded projects on the same topics.
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In-bed wearable rehab robot to help stroke survivors recover movement
A wearable robotic device will be developed to help adults who recently had an acute stroke regain movement while still in the hospital.
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When people are most at risk of another stroke after a minor stroke or TIA
Researchers are combining past trial data to find the timing of highest risk for a second stroke after a minor stroke or TIA so treatments can be better timed.
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Improving Participation after Stroke: Self-Management Rehab for Sub-Acute Stroke
A doctor- and patient-friendly program delivered virtually helps people who recently had a stroke feel more confident, stay active at home, and improve quality of life.
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Targeting a brain inflammation regulator to protect cells after a stroke
Aims to test a new approach that tampers with a key brain cell regulator to reduce inflammation and protect brain tissue after a stroke, potentially lowering disability.
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Predicting brain tissue outcome after acute stroke using AI
A researchers at Stanford are testing an AI system that uses brain scans and clinical data to predict which parts of the brain will recover after an acute stroke and how treatment might help.
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Helping brain recovery for people with severe paralysis after a recent stroke
This project builds a wearable in-bed robot to give gentle movement and sensory training to adults with severe weakness right after a stroke.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.