Understanding how neutrophils contribute to brain damage after a stroke
The Role of Neutrophils in Ischemia/Reperfusion Injury following Acute Stroke
This study is looking at how certain white blood cells called neutrophils affect inflammation and brain damage after a stroke, with the goal of finding new ways to help stroke patients recover better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10996186 on NIH RePORTER |
What this research studies
This research investigates the role of neutrophils, a type of white blood cell, in the inflammation that occurs after an ischemic stroke, where blood flow to the brain is blocked. The study aims to understand how these cells contribute to further brain injury following the restoration of blood flow. By examining the mechanisms of neutrophil migration into brain tissue, the research seeks to identify potential new therapeutic targets to improve outcomes for stroke patients. The approach involves both laboratory studies and analysis of inflammatory responses in animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an ischemic stroke and are within the critical time frame for therapeutic intervention.
Not a fit: Patients who have had hemorrhagic strokes or those who are outside the therapeutic window for intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that minimize brain damage and improve recovery for stroke patients.
How similar studies have performed: Previous research has shown that targeting inflammatory responses can improve outcomes in stroke models, suggesting that this approach has potential for success.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Arias, Erika — Northwestern University at Chicago
- Study coordinator: Arias, Erika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.