Using non-immunogenic staphylokinase to restore blood flow after ischemic stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project will collect clinical data from adults aged 18–85 with acute ischemic stroke who receive thrombolytic treatment with non-immunogenic staphylokinase in routine practice. Safety outcomes and clinical recovery measures will be recorded and compared to results from patients treated with the standard thrombolytic alteplase. Patients with known hypersensitivity to staphylokinase sequences, contraindications to thrombolysis, or who are pregnant or breastfeeding are excluded. Data collection occurs at the participating clinical site(s) and focuses on real-world effectiveness and adverse events following reperfusion therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-85 ;
* Diagnosis of acute ischemic stroke eligible for thrombolytic therapy;
* Thrombolytic therapy with the drug "non-immunogenic staphylokinase" is planned or has already been performed.

Exclusion Criteria:

* Individual intolerance or known hypersensitivity to a recombinant protein containing the amino acid sequence of staphylokinase;
* The presence of a contraindication to thrombolytic therapy of ischemic stroke;
* Pregnancy or lactation.

Where it's running

• St. Petersburg Research Institute of Emergency Medicine named after I.I. Janelidze
  Saint Petersburg, Russia Recruiting

Study contacts

• Study coordinator: Tatiana Kharitonova
• Email: tvh2001@mail.ru
• Phone: +79217450431

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Unimanual vs. Bimanual Motor Skill Learning After Stroke

  The study tests whether people with acute or chronic stroke, as well as healthy controls, can learn and remember a complex motor task using one hand or both, with robotic devices REAplan and Dextrain.

  Recruiting University Hospital of Mont-Godinne · Yvoir, Namur · NCT07826832

• Sarcopenia in older adults with acute ischemic stroke

  This study tests how common sarcopenia is in people 50 and older after an acute ischemic stroke and whether having sarcopenia at hospital admission is linked to worse outcomes three months later.

  Recruiting University Clinical Hospital na V.V.Vinogradov (branch of RUDN university na Patrice Lumumba) · Moscow · NCT07764172

• Low-Field MRI in Emergency Stroke Care

  This study tests whether a portable low-field MRI can help detect acute stroke in patients arriving with suspected stroke.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT07702968

• Best Care for Acute Stroke in General Wards

  A nurse-led program called BEST CARE ICTUS_HC is tested in hospitals without Stroke Units to see if it reduces stroke complications and helps recovery after an acute ischemic or hemorrhagic stroke.

  Recruiting University of Malaga · Antequera, Málaga and 3 other locations · NCT07627399

• Continuous Dual Aspiration with the Zoom System for Acute Ischemic Stroke

  This trial will try using the Zoom aspiration system with a continuous dual aspiration technique to remove clots in adults with acute ischemic stroke.

  Recruiting at 25 sites Imperative Care, Inc. · Huntsville, Alabama and 24 other locations · NCT07491952

• Using the mSOAR score to predict early death after an acute stroke

  This project will try the mSOAR score to see if it can predict early death in adults admitted with acute stroke at Sohag University Hospitals.

  Recruiting Sohag University · Sohag · NCT07355881

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.