When people are most at risk of another stroke after a minor stroke or TIA
Official title: Kinetic analysis of acute stroke secondary prevention trials: Insights from combined datasets guiding future trial design
Funded at University of Chicago · NIH-11416242 · Data updated 2026-11-12
Researchers are combining past trial data to find the timing of highest risk for a second stroke after a minor stroke or TIA so treatments can be better timed.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | December 1, 2023 |
| Project end | December 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $413,626 |
| NIH project number | 4R33NS135583-03 |
| Project ID | NIH-11416242 on NIH RePORTER |
Who could benefit from this research
✓Could help
People who recently had a minor ischemic stroke or a transient ischemic attack (TIA), especially within days to a few weeks of the event, would be the most relevant group for future trials informed by this work.
✕Less likely to help
People with hemorrhagic stroke, non-stroke neurological problems, or those whose stroke occurred many years ago are unlikely to directly benefit from this specific modeling project.
What this research studies
This project combines data from several past clinical trials to map how the risk of another ischemic stroke changes over time after a minor stroke or TIA. The team uses a mathematical 'kinetic' model that treats people as moving from a short-lived vulnerable state into a more stable state and estimates rates for those transitions and event risks. By fitting the model to trial results (including POINT, SOCRATES, and THALES), they aim to link different risk phases to likely biological mechanisms and to how treatments change those risks. The findings will be used to recommend timing and design features for future prevention trials and therapies.
Why it matters
Potential benefit: If successful, this work could help doctors and researchers choose the best timing and duration for medications to prevent early recurrent strokes.
How similar studies have gone: Large trials like POINT, SOCRATES, and THALES showed high early recurrence risk and short-term treatment effects, and this project builds on those real-world trial results with a formal kinetic model.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Brorson, James R. — University of Chicago
- Study coordinator: Brorson, James R.
Related research
Other NIH-funded projects on the same topics.
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In-bed wearable rehab robot to help stroke survivors recover movement
A wearable robotic device will be developed to help adults who recently had an acute stroke regain movement while still in the hospital.
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Improving Participation after Stroke: Self-Management Rehab for Sub-Acute Stroke
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Targeting a brain inflammation regulator to protect cells after a stroke
Aims to test a new approach that tampers with a key brain cell regulator to reduce inflammation and protect brain tissue after a stroke, potentially lowering disability.
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Predicting brain tissue outcome after acute stroke using AI
A researchers at Stanford are testing an AI system that uses brain scans and clinical data to predict which parts of the brain will recover after an acute stroke and how treatment might help.
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Helping brain recovery for people with severe paralysis after a recent stroke
This project builds a wearable in-bed robot to give gentle movement and sensory training to adults with severe weakness right after a stroke.
-
Language recovery after stroke: how people regain communication skills and how to help
A Johns Hopkins team is studying how people recover language after a left-hemisphere stroke and what helps them regain reading, spelling, and understanding spoken and written language.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.