Boosting surface brain vessel blood flow during large strokes
Targeting Pial Collaterals for Acute Stroke Treatment
['FUNDING_R01'] · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · NIH-11057594
This project tests treatments to keep tiny surface brain vessels open during a major ischemic stroke to help people—especially those with chronic high blood pressure—save more brain tissue.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VERMONT & ST AGRIC COLLEGE (nih funded) |
| Locations | 1 site (BURLINGTON, UNITED STATES) |
| Trial ID | NIH-11057594 on ClinicalTrials.gov |
What this research studies
You would hear that researchers are focused on the pial collaterals, small surface brain vessels that can keep blood flowing to threatened brain tissue during a large-vessel stroke. In lab studies they compare vessels from animals with normal blood pressure and with chronic hypertension to see why high blood pressure causes these vessels to constrict and fail. The team studies molecules such as angiotensin II and PAI-1 that drive vessel tightening and tests ways to prevent that constriction so the penumbra gets more blood. The long-term aim is to develop treatments that could be used during or soon after a large-vessel stroke to preserve brain tissue and improve recovery.
Who could benefit from this research
Good fit: People who have had or are at high risk for acute large-vessel ischemic stroke—particularly those with chronic high blood pressure—would be the most relevant candidates for related trials.
Not a fit: People with bleeding (hemorrhagic) stroke, small-vessel stroke types, or conditions unrelated to large-vessel ischemia are unlikely to benefit from these specific approaches.
Why it matters
Potential benefit: If successful, this work could lead to treatments that preserve more brain tissue during large-vessel strokes and improve recovery, especially for people with chronic hypertension.
How similar studies have performed: Prior animal studies, including this team's published work, suggest that targeting angiotensin II–related vessel constriction can improve collateral flow, but successful translation to people remains unproven.
Where this research is happening
BURLINGTON, UNITED STATES
- UNIVERSITY OF VERMONT & ST AGRIC COLLEGE — BURLINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CIPOLLA, MARILYN J — UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
- Study coordinator: CIPOLLA, MARILYN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.