Analyzing non-coding RNA in patients with acute ischemic stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the expression patterns of circular RNA (circRNA), micro-RNA (miRNA), and long non-coding RNA (lncRNA) in patients diagnosed with acute ischemic stroke compared to healthy controls. Using next-generation sequencing, the study aims to identify distinctive expression patterns of these non-coding RNAs that may serve as biomarkers for the detection and prognosis of acute ischemic stroke. The findings will be validated through quantitative real-time polymerase chain reaction (qRT-PCR) and a diagnostic model will be developed using logistic regression to assess the clinical significance of these biomarkers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18 years or older
* Confirmed acute ischemic stroke by a diffusion-weighted imaging-position lesion on magnetic resonance imaging (MRI) and a new lesion on a brain computed tomography (CT) scan
* Within 72 hours of symptom onset
* Good performance status
* Signed an approved informed consents

Exclusion Criteria:

-a history of hemorrhagic infarction, chronic kidney/liver diseases, peripheral arterial occlusive disease, active malignant disease, and inflammatory or infectious diseases

Where it's running

• Nanjing First Hospital, Nanjing Medical University
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Junshan Zhou, M.D.
• Email: zhjsh333@126.com
• Phone: +8602587726218

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.