Detecting brain injuries in children on ECMO using portable MRI

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the prevalence and types of acute brain injury (ABI) in pediatric patients who are undergoing extracorporeal membrane oxygenation (ECMO) support. It utilizes an ultralow-field portable MRI system to monitor brain health at the bedside, addressing the limitations of traditional imaging methods that are not compatible with ECMO devices. By evaluating the time course and rates of ABI in relation to ECMO duration and routine clinical imaging, the study seeks to improve early detection and intervention for brain injuries in critically ill children. The research focuses on patients aged 0-17 years who are at high risk for ECMO.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants that will be or are admitted to the Pediatric Intensive Care Unit, Cardiac Intensive Care Unit, or the Neonatal Intensive Care Unit
* Ages 0-17 years
* Participants that are at high risk for undergoing ECMO or are currently undergoing venovenous or venoarterial ECMO

  • High risk participants include, but are not limited to:
* Undergoing cardiac surgery
* Congenital heart disease
* Congenital diaphragmatic hernia
* Refractory hypoxemic and/or hypercarbic respiratory failure
* Vasoactive-refractory shock

Exclusion Criteria:

* Pregnancy
* Any patient who has a contraindication to having an MRI
* Patients with a passive or active implant will:

  * First be reviewed on MRISafety.com to determine MR conditionality
  * If device is listed as Conditional or Unsafe for a 1.5T or a 3T, device will then be reviewed by MRI Safety Officer or MRI Physician Section chief to determine true conditionality for the portable MRI

Where it's running

• Children's Mercy
  Kansas City, Missouri, United States Recruiting

Study contacts

• Principal investigator: Jessica Wallisch, MD — Children's Mercy Kansas City
• Study coordinator: Maura Sien, MSML, CCRC
• Email: mesien@cmh.edu
• Phone: 8163028311

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.