Portable MRI for kids with hypoxic brain injury
Official title: Ultralow-Field Portable MRI for Detection of Pediatric Hypoxic Ischemic Brain Injury
Run by Children's Mercy Hospital Kansas City · NCT07577336 · Data updated 2026-11-12
This study tests whether a bedside, low-field portable MRI can accurately detect hypoxic-ischemic brain injuries in children compared with standard imaging.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | Any age to 17 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Children's Mercy Hospital Kansas City Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Kansas City, Missouri) |
| Status | Recruiting |
| Started | July 6, 2026 |
| Main results expected | December 2027 |
| Study ends | December 2027 |
| Registry record updated | September 24, 2026 |
| Trial ID | NCT07577336 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children aged 0-17 years in PICU, CICU, or NICU with acute neurologic deficits suspected from HIBI or high risk for HIBI.
✕Probably not a fit
Patients without suspected hypoxic-ischemic brain injury or those whose imaging findings are already definitive may obtain no additional benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will compare the sensitivity and specificity of bedside portable MRI to clinically obtained neuroimaging in pediatric patients with suspected hypoxic-ischemic brain injury. The trial will enroll children up to 17 years old in intensive care settings and will use scavenged sample collection alongside the portable MRI. The goal is to define diagnostic limits and identify optimal clinical use of this imaging modality in pediatric care. Standard MRI remains the reference, but portable MRI offers bedside access, fewer risks, and reduced noise for critically ill patients. Outcomes will inform how and when to adopt portable MRI in pediatric neurocritical care.
Why it matters
Potential benefit: If successful, bedside portable MRI could enable faster, safer brain imaging for critically ill children with hypoxic-ischemic injury.
How similar studies have gone: Prior efforts with portable MRI in pediatric or critical care settings show promise but are still exploratory for hypoxic-ischemic injury.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients hospitalized in the Pediatric Intensive Care Unit, Cardiac Intensive Care Unit, or the Neonatal Intensive Care Unit * Ages 0-17 years at study enrollment * Acute neurologic deficit suspected secondary to Hypoxic Ischemic Brain Injury (HIBI) or patients at high risk for HIBI Exclusion Criteria: * Pregnancy * Any patient who has a contraindication to having an MRI Patients with a passive or active implant will: * First be reviewed on MRISafety.com to determine MR conditionality * If the device is listed as Conditional or Unsafe for a 1.5T or a 3T, the device will then be reviewed by the MRI Safety Officer or MRI Physician Section chief to determine true conditionality for the portable MRI
Where it's running
-
Children's Mercy Kansas City
Kansas City, Missouri, United States Recruiting
Study contacts
- Principal investigator: Jessica S Wallisch, MD — Children's Mercy Kansas City
- Study coordinator: Jessica S Wallisch, MD
- Email: jwallisch@cmh.edu
- Phone: (816) 816-7929
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Deep phenotyping to explore recovery in young adults after stroke
This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.
-
Stem cell therapy for chronic stroke recovery
This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.
-
How changes in brain blood flow affect breathing during sleep
This project will test whether temporarily lowering blood flow to the brain changes how healthy adults' breathing responds to low oxygen and high carbon dioxide during normal sleep and short periods of low oxygen.
-
AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals
This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.
-
Web-based therapy using action observation and mirror therapy for arm weakness after stroke
This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.
-
Remote Ischaemic Conditioning for Fatigue After Stroke 2
Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.