Understanding how brain injuries affect neuron function and swelling
Neuronal Ion and Volume Shifts After Acute Brain Injury
This study looks at how sudden brain injuries affect the balance of important minerals in brain cells and how this can lead to swelling, especially in babies and young children, with the goal of finding better ways to treat these injuries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11082220 on NIH RePORTER |
What this research studies
This research investigates the effects of acute brain injuries on neuronal ion balance and volume regulation. It focuses on how changes in ion homeostasis and membrane permeability can lead to brain swelling and cytotoxic edema, particularly in both mature and immature brains. The study aims to identify the mechanisms behind these changes and their implications for treatment, especially in vulnerable populations like premature infants. By exploring these processes, the research seeks to develop better therapeutic strategies for managing brain injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced acute brain injuries, particularly premature infants and those with neonatal seizures.
Not a fit: Patients with chronic brain conditions or those who have not experienced acute brain injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for brain injuries, particularly in neonates and infants who currently have limited options.
How similar studies have performed: Other research has shown promise in understanding neuronal ion homeostasis and its implications for brain injury, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Staley, Kevin J. — Massachusetts General Hospital
- Study coordinator: Staley, Kevin J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.