Comparing EEG-guided treatments for seizures in patients with acute brain injuries
Official title: Comparative Effectiveness of EEG-Guided Anti-Seizure Treatment in Acute Brain Injury
Funded at Massachusetts General Hospital · NIH-10993209 · Data updated 2026-11-12
This study is looking at how well EEG-guided treatments can help reduce seizures in people who have had serious brain injuries, like strokes or trauma, to improve their recovery and overall health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $591,352 |
| NIH project number | 5R01NS131347-02 |
| Project ID | NIH-10993209 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an acute brain injury and are at risk for seizures.
✕Less likely to help
Patients who do not have acute brain injuries or are not at risk for seizures may not benefit from this research.
What this research studies
This research investigates the effectiveness of EEG-guided anti-seizure treatments for patients suffering from acute brain injuries, such as strokes or trauma. It aims to understand how these treatments can reduce seizure activity, which is common in this patient population and can lead to increased risks of death and disability. By utilizing a large multi-center EEG registry, the study will analyze EEG data to better inform treatment decisions and improve patient outcomes. The research addresses the challenges of balancing the adverse effects of seizures with the side effects of anti-seizure medications.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatment options for patients with acute brain injuries at risk of seizures.
How similar studies have gone: Previous research has shown promise in using EEG data to guide treatment decisions in similar patient populations, indicating that this approach may be effective.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Zafar, Sahar F — Massachusetts General Hospital
- Study coordinator: Zafar, Sahar F
Related research
Other NIH-funded projects on the same topics.
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This project will use computer-based EEG tools to help doctors predict recovery and seizure risk for people hospitalized with sudden (acute) brain injuries.
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Using EEG to guide seizure medicines after stroke or head injury
This project looks at whether using bedside EEG brain monitoring to guide anti-seizure medicines for people with recent stroke or traumatic brain injury can prevent harmful brain activity while cutting down medicine side effects.
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Understanding Brain Injury During ECMO Treatment
This research looks at why some people develop brain injury when they receive life-saving ECMO support for severe heart and lung failure.
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Helping patients with acute brain injuries and their caregivers build resilience together
This study is for patients who have had a brain injury, like a stroke, and their caregivers, and it offers a friendly program called 'Recovering Together' to help them cope with stress and support each other while they heal in the hospital.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.