NIH-funded research NIH-funded research

Monitoring brain conditions using a single device for acute injuries

Official title: Intracranial multimodal physiological monitoring in acute brain injury

Funded at Yale University · NIH-10920380 · Data updated 2026-11-12

This study is testing a new device called the NeuroProbe that will help doctors keep a closer eye on brain injuries by measuring important things like pressure and oxygen levels in one small, easy-to-use tool, making it safer and simpler for patients.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionYale University
NIH-funded
Lab location1 site (New Haven, United States)
Project startAugust 15, 2022
Project endJuly 31, 2025
Funding year2024
Award (this year)$1,603,729
NIH project number5UG3NS123307-03
Project IDNIH-10920380 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals suffering from acute brain injuries, particularly those requiring intensive monitoring.

Less likely to help

Patients with non-acute brain conditions or those who do not require invasive monitoring may not benefit from this research.

What this research studies

This research aims to improve the monitoring of acute brain injuries by developing a single device that can measure multiple critical parameters, such as intracranial pressure and brain tissue oxygen levels. Currently, monitoring requires several invasive probes, which complicates the process and increases risks for patients. The new device, called the NeuroProbe, will be smaller and designed to integrate various monitoring functions into one system, making it easier to use in clinical settings. The goal is to enhance patient care by providing comprehensive data with reduced invasiveness.

Why it matters

Potential benefit: If successful, this research could lead to safer and more effective monitoring of patients with severe brain injuries, potentially improving outcomes.

How similar studies have gone: Previous research has shown promise in multimodal monitoring approaches, but this specific integration of technologies is novel.

Where this research is happening

  • Yale University
    New Haven, United States
    Active

Researchers

  • Principal investigator: Spencer, Dennis D — Yale University
  • Study coordinator: Spencer, Dennis D

Related research

Other NIH-funded projects on the same topics.

  • Sleep patterns predicting recovery after acute brain injury

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    NIH research Columbia University Health Sciences · New York, United States · NIH-11458485

  • Brain cell ion balance and swelling after sudden brain injury

    They are looking at how changes in ion levels and cell size after a sudden brain injury cause swelling or shrinkage for people with acquired brain injuries, including newborns.

    NIH research Massachusetts General Hospital · Boston, United States · NIH-11324023

  • EEG tools to predict recovery after sudden brain injury

    This project will use computer-based EEG tools to help doctors predict recovery and seizure risk for people hospitalized with sudden (acute) brain injuries.

    NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11243554

  • Using EEG to guide seizure medicines after stroke or head injury

    This project looks at whether using bedside EEG brain monitoring to guide anti-seizure medicines for people with recent stroke or traumatic brain injury can prevent harmful brain activity while cutting down medicine side effects.

    NIH research Massachusetts General Hospital · Boston, United States · NIH-11235864

  • Understanding Brain Injury During ECMO Treatment

    This research looks at why some people develop brain injury when they receive life-saving ECMO support for severe heart and lung failure.

    NIH research Johns Hopkins University · Baltimore, United States · NIH-11163474

  • Helping patients with acute brain injuries and their caregivers build resilience together

    This study is for patients who have had a brain injury, like a stroke, and their caregivers, and it offers a friendly program called 'Recovering Together' to help them cope with stress and support each other while they heal in the hospital.

    NIH research Massachusetts General Hospital · Boston, United States · NIH-11090444

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.