Monitoring brain activity and health in patients with severe brain injuries
Official title: Intracranial multimodal physiological monitoring in acute brain injury
Funded at Yale University · NIH-11067148 · Data updated 2026-11-12
This study is testing a new device called the NeuroProbe that will help doctors keep a closer eye on patients with serious brain injuries by combining several monitoring tools into one, making it easier and safer for you during treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 15, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $688,911 |
| NIH project number | 3UG3NS123307-03S1 |
| Project ID | NIH-11067148 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from acute traumatic brain injuries, particularly those requiring intensive monitoring.
✕Less likely to help
Patients with mild brain injuries or those who do not require invasive monitoring may not benefit from this research.
What this research studies
This research aims to improve the monitoring of patients with acute brain injuries by developing a new device that combines multiple monitoring functions into one implantable solution. Currently, monitoring requires several invasive probes, which can be cumbersome and risky. The new device, called the NeuroProbe, will measure critical parameters like intracranial pressure and brain tissue oxygen, while the NeuroLink will collect and integrate this data with other physiological information. This streamlined approach could enhance patient care and outcomes in severe traumatic brain injury cases.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective monitoring of brain health in patients with severe brain injuries.
How similar studies have gone: Previous research has shown promise in multimodal monitoring approaches for brain injuries, indicating potential for success with this integrated device.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Spencer, Dennis D — Yale University
- Study coordinator: Spencer, Dennis D
Related research
Other NIH-funded projects on the same topics.
-
Sleep patterns predicting recovery after acute brain injury
Researchers will look at brain sleep signals to see if certain sleep patterns can forecast when patients who are unconscious after a brain injury may start to wake up and recover.
-
Brain cell ion balance and swelling after sudden brain injury
They are looking at how changes in ion levels and cell size after a sudden brain injury cause swelling or shrinkage for people with acquired brain injuries, including newborns.
-
EEG tools to predict recovery after sudden brain injury
This project will use computer-based EEG tools to help doctors predict recovery and seizure risk for people hospitalized with sudden (acute) brain injuries.
-
Using EEG to guide seizure medicines after stroke or head injury
This project looks at whether using bedside EEG brain monitoring to guide anti-seizure medicines for people with recent stroke or traumatic brain injury can prevent harmful brain activity while cutting down medicine side effects.
-
Understanding Brain Injury During ECMO Treatment
This research looks at why some people develop brain injury when they receive life-saving ECMO support for severe heart and lung failure.
-
Helping patients with acute brain injuries and their caregivers build resilience together
This study is for patients who have had a brain injury, like a stroke, and their caregivers, and it offers a friendly program called 'Recovering Together' to help them cope with stress and support each other while they heal in the hospital.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.