NIH-funded research R01 grant

Understanding outcomes and care needs after severe brain injuries

Official title: Comprehensive Outcome Assessment after Severe Acute Brain Injury: Advanced Symptoms and End-of-Life Care Needs

Funded at University of Washington · NIH-11085958 · Data updated 2026-11-12

This study is looking at how people who have had serious brain injuries, like strokes or heart attacks, are doing in their final weeks of life and how we can make their care better, while also understanding how this affects their family members who are helping them.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Washington
NIH-funded
Lab location1 site (Seattle, United States)
Project startMay 12, 2021
Project endMarch 31, 2026
Funding year2025
Award (this year)$558,847
NIH project number5R01NR019268-05
Project IDNIH-11085958 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals who have suffered from severe acute vascular brain injuries, such as ischemic strokes or cardiac arrests.

Less likely to help

Patients with chronic conditions unrelated to acute brain injuries may not benefit from this research.

What this research studies

This research investigates the outcomes and care needs of patients who have experienced severe acute vascular brain injuries, such as strokes or cardiac arrests. It aims to gather comprehensive data on the symptoms these patients face over time, particularly in the last weeks of life, and how their care transitions can be improved. The study also focuses on the psychological impact on family members who act as caregivers and decision-makers. By addressing these aspects, the research seeks to enhance the quality of care and support for both patients and their families.

Why it matters

Potential benefit: If successful, this research could lead to improved care strategies and support systems for patients with severe brain injuries and their families.

How similar studies have gone: While there has been significant research on palliative care in other serious illnesses, this approach to severe acute vascular brain injuries is relatively novel and has not been extensively tested.

Where this research is happening

  • University of Washington
    Seattle, United States
    Active

Researchers

  • Principal investigator: Creutzfeldt, Claire Johanna — University of Washington
  • Study coordinator: Creutzfeldt, Claire Johanna

Related research

Other NIH-funded projects on the same topics.

  • Sleep patterns predicting recovery after acute brain injury

    Researchers will look at brain sleep signals to see if certain sleep patterns can forecast when patients who are unconscious after a brain injury may start to wake up and recover.

    NIH research Columbia University Health Sciences · New York, United States · NIH-11458485

  • Brain cell ion balance and swelling after sudden brain injury

    They are looking at how changes in ion levels and cell size after a sudden brain injury cause swelling or shrinkage for people with acquired brain injuries, including newborns.

    NIH research Massachusetts General Hospital · Boston, United States · NIH-11324023

  • EEG tools to predict recovery after sudden brain injury

    This project will use computer-based EEG tools to help doctors predict recovery and seizure risk for people hospitalized with sudden (acute) brain injuries.

    NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11243554

  • Using EEG to guide seizure medicines after stroke or head injury

    This project looks at whether using bedside EEG brain monitoring to guide anti-seizure medicines for people with recent stroke or traumatic brain injury can prevent harmful brain activity while cutting down medicine side effects.

    NIH research Massachusetts General Hospital · Boston, United States · NIH-11235864

  • Understanding Brain Injury During ECMO Treatment

    This research looks at why some people develop brain injury when they receive life-saving ECMO support for severe heart and lung failure.

    NIH research Johns Hopkins University · Baltimore, United States · NIH-11163474

  • Helping patients with acute brain injuries and their caregivers build resilience together

    This study is for patients who have had a brain injury, like a stroke, and their caregivers, and it offers a friendly program called 'Recovering Together' to help them cope with stress and support each other while they heal in the hospital.

    NIH research Massachusetts General Hospital · Boston, United States · NIH-11090444

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.