Sponsor or institution
Clinical trials and research at University of Toledo
As of November 12, 2026, Find a Trial lists 34 NIH-funded research projects at this institution, with $13.5 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 34NIH research projects
NIH-funded research (34)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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How Zika Virus Can Weaken Eye Barriers and What Might Help
Researchers are studying how Zika virus may disrupt the eye’s protective barrier in newborns and whether certain pathways could be targeted to protect vision.
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Role of Protocadherin 19 in human cortical development and its link to epilepsy
A study using human stem cell–derived brain models to understand how PCDH19 gene variants affect early brain development and contribute to epilepsy.
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How tiny RNAs help guide nerve fibers in autism
A study in chicken models looks at how specific microRNAs control nerve-fiber guidance receptors to help proper brain wiring relevant to autism.
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Centrosomal JAK2 in ciliated cells impacts ciliogenesis and cell behavior
A research grant aims to understand how JAK2 at the centrosome affects ciliogenesis and related cell functions in conditions like Alzheimer’s disease.
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Sperm Centriole Mechanism in Fertilization
Researchers are studying how human sperm centrioles and the neck connect to the tail to enable fertilization, using rabbits as a genetic model to uncover this mechanism.
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Dynamic covalent chemistry enables remote C-H changes on alkaloids
A new method uses special temporary directing groups to modify hard-to-reach parts of alkaloid molecules, potentially expanding how these natural-product-derived compounds are customized.
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Understanding how Gfi1 and C/EBPα steer neutrophil formation in the blood
A scientist team at the University of Toledo is studying why certain blood cells become neutrophils or monocytes, with the aim of finding ways to help people with low neutrophil counts.
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How polycystin proteins control cell size
Researchers are learning how polycystin proteins and calcium signals control cell growth in ways that relate to autosomal dominant polycystic kidney disease (ADPKD).
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New approach to antifungal drugs that permanently disable fungal targets
A new type of antifungal drug approach aims to permanently inactivate a fungal enzyme to kill or stop drug-resistant fungi.
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New enzymes from the human gut and archaea that make halogenated chemicals
Scientists are looking for enzymes in gut microbes and archaea that can make chlorinated and brominated chemicals useful for greener drug-making.
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Understanding how smell influences behavior using tiny worms
This study looks at how the sense of smell influences behavior and body responses using tiny worms, and it aims to help us understand how smell might affect things like appetite in humans too.
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Investigating how immune cells in the mouth respond to infections caused by Candida.
This study is looking at how certain immune cells in your mouth react during Candida infections, especially for those with weakened immune systems, to find better ways to treat these infections.
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Understanding how polycystins control cell size during growth
This study is looking at how certain proteins called polycystins help control cell size during growth, using fission yeast as a model, to better understand the processes that might be involved in conditions like Autosomal Dominant Polycystic Kidney Disease (ADPKD).
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Developing advanced microscopy techniques for faster cancer drug discovery
This study is working on a special microscope to help scientists see how cancer cells die, which could lead to faster discoveries of new cancer treatments, and it also aims to teach college students from diverse backgrounds how to use these cool new tools.
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Investigating the composition of sperm structures in cattle
This study is looking at special parts of cow sperm that help it swim and could affect how well it fertilizes eggs, which might give us important clues about reproduction and early embryo development.
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Investigating how a specific gene affects cell division and mitochondrial function
This study is looking at how a specific gene called MTFR2 affects the way cancer cells divide and how problems with cell energy can lead to mistakes during this process, which could help us find better ways to treat certain types of cancer.
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Identifying and studying toxic compounds from harmful algae blooms
This study is looking at harmful substances made by blue-green algae in Lake Erie to see how they affect liver and kidney cells, helping us find better ways to keep our water safe during these algae blooms.
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Understanding how a specific protein affects cell junctions in epithelial tissues
This study is looking at how a protein called SGEF helps keep the connections between cells strong and stable, which is important for the health of tissues in our body, and it could help us understand more about conditions that affect these connections.
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A program to teach biomedical engineering students how to create medical devices based on real healthcare needs.
This study is creating a hands-on learning program for biomedical engineering students to help them understand real healthcare problems and come up with creative solutions for medical devices, so they can better prepare for working in the healthcare field.
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Developing new methods for creating important chemical compounds
This study is working on making special molecules that can help create new medicines and treatments, using easier and more efficient methods, which could eventually lead to better health options for patients.
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Investigating how a specific gene affects cell division and cancer development
This study is looking at how a specific gene called MTFR2 affects how cancer cells divide and manage their energy, which could help us understand why some cancer cells behave differently and become unstable.
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How MLK3 affects cell adhesion in cancer cells
This study is looking at how a protein called MLK3 affects how ovarian and breast cancer cells stick together and move around, which could help us understand how cancer spreads and find new ways to treat it.
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Creating new vaccines to fight antibiotic-resistant bacteria
This study is working on new vaccines to help fight tough infections caused by antibiotic-resistant bacteria, like Pseudomonas aeruginosa, so that patients can have better treatment options for these challenging infections.
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Developing advanced microscopy techniques to discover new cancer treatments
This study is working on a new tool that helps scientists see how cancer drugs kill cancer cells in real time, which could lead to better treatments for patients with tough-to-treat cancers.
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Understanding how stress granules respond to viral infections
This study is looking at how tiny structures in our cells, called stress granules, help our bodies fight off viruses when we're stressed, and it aims to find out how these granules work and how they might lead to new treatments.
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Understanding how rabbit sperm centrioles function
This study looks at how tiny structures called centrioles in rabbit sperm change during their development, which might help improve sperm movement and function, and it aims to find new ways to understand and treat male infertility for couples trying to conceive.
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Developing new methods to create sugars from bacteria for vaccines
This study is working on new ways to make special sugars from bacteria that can help create better vaccines to fight infections, especially those caused by drug-resistant bacteria, so we can have more options beyond antibiotics.
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Investigating how a specific gene affects cell division and cancer development
This study is looking at how a specific gene called MTFR2 affects the way cancer cells divide and how problems with cell energy can lead to mistakes in their genetic material, which could help us find new ways to treat cancer.
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Understanding how microRNAs control nerve cell growth and direction
This study is looking at how tiny molecules called microRNAs help guide the growth and connections of nerve cells, using chicken embryos and mice, to better understand what goes wrong in neurological disorders and how we might help treat them.
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Exploring new enzymes from gut bacteria that can create useful chemical compounds
This study is looking at special enzymes made by bacteria in our gut that can help create useful chemicals, which could lead to greener ways of making products and help us understand how our gut bacteria affect our health.
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How prolactin from fat cells affects breast cancer progression
This study is looking at how a hormone called prolactin, made by fat cells, might help breast cancer grow and spread, with the hope of finding new ways to predict and treat the disease for patients.
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Targeting a specific enzyme to treat liver disease caused by alcohol consumption
This study is looking at how a specific protein called PDE4B affects liver problems caused by drinking too much alcohol, and it aims to find out if blocking this protein can help reduce liver damage and inflammation, potentially leading to better treatments for people with alcohol-related liver disease.
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Investigating the role of CDHR5 in preventing colorectal cancer
This study is looking at how a protein called CDHR5 helps keep our intestines healthy and may prevent colorectal cancer, and it’s exploring whether a medication called 5-ASA can boost this protein's protective effects to help develop better ways to prevent this type of cancer.
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Investigating how certain proteins influence the development of blood cells.
This study is looking at how certain proteins help shape the development of important blood cells, like neutrophils and monocytes, which could lead to better ways to treat infections and blood disorders for patients.
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