Investigating how a specific gene affects cell division and mitochondrial function
Official title: MTFR2 in the control of mitochondrial dynamics and mitotic spindle integrity
Funded at University of Toledo · NIH-11031534 · Data updated 2026-11-12
This study is looking at how a specific gene called MTFR2 affects the way cancer cells divide and how problems with cell energy can lead to mistakes during this process, which could help us find better ways to treat certain types of cancer.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project start | December 10, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $42,419 |
| NIH project number | 3R15GM147878-01S2 |
| Project ID | NIH-11031534 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with cancers characterized by chromosomal instability or those interested in the genetic factors influencing cancer progression.
✕Less likely to help
Patients with non-cancerous conditions or those whose cancers do not involve chromosomal instability may not benefit from this research.
What this research studies
This research focuses on understanding the role of the MTFR2 gene in regulating mitochondrial dynamics and its impact on cell division, particularly in cancer cells. The researchers will use advanced techniques, including CRISPR, to manipulate the MTFR2 gene and observe its effects on chromosome segregation during mitosis. By studying how defects in mitochondrial function can lead to errors in cell division, the research aims to uncover new insights into cancer cell behavior and potential therapeutic targets. Patients may benefit from this research as it could lead to improved understanding and treatment of cancers associated with chromosomal instability.
Why it matters
Potential benefit: If successful, this research could provide new insights into cancer treatment by targeting the mechanisms of cell division and mitochondrial function.
How similar studies have gone: Other research has shown promising results in understanding the relationship between mitochondrial function and cancer cell behavior, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Toledo
Toledo, United States Active
Researchers
- Principal investigator: Liu, Song-Tao — University of Toledo
- Study coordinator: Liu, Song-Tao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.